AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Virologie, F-75013 Paris, France.
AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Virologie, F-75013 Paris, France.
J Clin Virol. 2023 Jul;164:105446. doi: 10.1016/j.jcv.2023.105446. Epub 2023 Apr 14.
Diagnosis of Human T-cell Lymphotropic Virus (HTLV) types I and II infection requires sequencial testing with firstly a screening using an Enzyme immunoassay followed by a confirmatory test.
To compare the performances of the Alinity i rHTLV-I/II (Abbott®) and LIAISON® XL murex recHTLV-I/II serological screening tests to the ARCHITECT rHTLVI/II test followed if positive by HTLV BLOT 2.4, MP Diagnostics as the reference.
119 serum samples from 92 known HTLV-I infected patients and 184 from uninfected patients with HTLV were analyzed in parallel with, Alinity i rHTLV-I/II, LIAISON® XL murex recHTLV-I/II and ARCHITECT rHTLVI/II.
Alinity i rHTLV-I/II and LIAISON® XL murex recHTLV-I/II exhibited a total agreement with ARCHITECT rHTLVI/II for both positive and negative samples. Both tests are suitable alternatives for HTLV screening.
人类 T 细胞嗜淋巴细胞病毒（HTLV）I 型和 II 型感染的诊断需要通过酶免疫测定进行顺序检测，首先是使用筛选试验，然后是确认试验。
比较 Alinity i rHTLV-I/II（雅培）和 LIAISON XL murex recHTLV-I/II 血清学筛选试验与 ARCHITECT rHTLVI/II 试验的性能，阳性样本则采用 MP 诊断 HTLV BLOT 2.4 进行确认，以作为参考。
对 92 例已知 HTLV-I 感染患者和 184 例未感染患者的 119 份血清样本进行平行分析，检测 Alinity i rHTLV-I/II、LIAISON XL murex recHTLV-I/II 和 ARCHITECT rHTLVI/II。
Alinity i rHTLV-I/II 和 LIAISON XL murex recHTLV-I/II 与 ARCHITECT rHTLVI/II 对阳性和阴性样本均显示出完全一致的结果。这两种检测方法都适合作为 HTLV 筛查的替代方法。
