• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一种新型的高通量快速筛选试验，用于检测 HTLV-I/II 感染患者体内的总 HTLV-I 和 HTLV-II 抗体。

A novel high-performance rapid screening test for the detection of total HTLV-I and HTLV-II antibodies in HTLV-I/II infected patients.

机构信息

Department of Research and Development, MP Biomedicals Asia Pacific Pte Ltd, Singapore, Singapore.

Laboratoire de Virologie Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Paris, France.

出版信息

BMC Infect Dis. 2024 Aug 26;24(1):860. doi: 10.1186/s12879-024-09791-2.

DOI:10.1186/s12879-024-09791-2
PMID:39187753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346188/
Abstract

Rapid diagnosis of human T-cell lymphotropic virus (HTLV) type-I and -II infections are essential for timely and cost-effective disease interventions. MP Diagnostics ASSURE HTLV-I/II Rapid Test was developed for the rapid detection of anti-HTLV-I/II antibodies in patients' serum, plasma, and whole blood specimens. ASSURE HTLV-I/II Rapid Test employed MP Biomedicals' proprietary HTLV-I/II Trifusion recombinant antigen conjugated with gold nanoparticles and HTLV-I / HTLV-II recombinant antigens immobilized on the nitrocellulose membrane to detect total HTLV-I and HTLV-II antibodies. The overall performance of the ASSURE HTLV-I/II Rapid Test was found to be 99.42% sensitivity (95% Confidence Interval, 98.32-99.88%) and 100% specificity (95% Confidence Interval, 99.58-100.00%) in the tested clinical samples, including a total of 518 HTLV-I/II positive specimens (396 HTLV-I infection, 97 HTLV-II infection and 25 HTLV-I/II dual infection) and 872 HTLV negative clinical specimens consisting of 691 healthy donor samples, 116 potentially cross-reactive samples, and 65 samples with interfering substances. The ASSURE HTLV-I/II Rapid Test can effectively be deployed as a screening tool in any prevalence studies, blood banks or organ transplant centres.

摘要

快速诊断人类 T 细胞嗜淋巴细胞病毒 (HTLV) 型-I 和 -II 感染对于及时和具有成本效益的疾病干预至关重要。MP 诊断公司的 ASSURE HTLV-I/II 快速检测试剂盒用于快速检测患者血清、血浆和全血样本中的抗-HTLV-I/II 抗体。ASSURE HTLV-I/II 快速检测试剂盒采用 MP 生物医学公司专有的 HTLV-I/II Trifusion 重组抗原与金纳米颗粒偶联，并将 HTLV-I/HTLV-II 重组抗原固定在硝酸纤维素膜上，以检测总 HTLV-I 和 HTLV-II 抗体。在测试的临床样本中，ASSURE HTLV-I/II 快速检测试剂盒的整体性能为 99.42%的灵敏度（95%置信区间，98.32-99.88%）和 100%的特异性（95%置信区间，99.58-100.00%），包括总共 518 份 HTLV-I/II 阳性样本（396 份 HTLV-I 感染、97 份 HTLV-II 感染和 25 份 HTLV-I/II 双重感染）和 872 份 HTLV 阴性临床样本，其中包括 691 份健康供体样本、116 份潜在交叉反应性样本和 65 份有干扰物质的样本。ASSURE HTLV-I/II 快速检测试剂盒可有效用作任何流行率研究、血库或器官移植中心的筛查工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74a/11346188/ffcee21cc3b6/12879_2024_9791_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74a/11346188/265cea652a49/12879_2024_9791_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74a/11346188/ffcee21cc3b6/12879_2024_9791_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74a/11346188/265cea652a49/12879_2024_9791_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c74a/11346188/ffcee21cc3b6/12879_2024_9791_Fig2_HTML.jpg

相似文献

1
A novel high-performance rapid screening test for the detection of total HTLV-I and HTLV-II antibodies in HTLV-I/II infected patients.一种新型的高通量快速筛选试验，用于检测 HTLV-I/II 感染患者体内的总 HTLV-I 和 HTLV-II 抗体。
BMC Infect Dis. 2024 Aug 26;24(1):860. doi: 10.1186/s12879-024-09791-2.
2
Evaluation of a new screening assay for HTLV-1 and -2 antibodies for large-scale use.评价一种新的用于大规模使用的 HTLV-1 和 -2 抗体的筛查检测方法。
J Med Virol. 2010 Sep;82(9):1606-11. doi: 10.1002/jmv.21867.
3
Strategies for diagnosis of HTLV-I and -II.人类嗜T淋巴细胞病毒I型和II型的诊断策略。
Transfusion. 2002 Jun;42(6):780-91. doi: 10.1046/j.1537-2995.2002.00114.x.
4
Modified Western blot assay for confirmation and differentiation of human T cell lymphotropic virus types I and II.用于确认和区分人类I型和II型嗜T细胞病毒的改良蛋白质印迹法。
J Infect Dis. 1991 Aug;164(2):400-3. doi: 10.1093/infdis/164.2.400.
5
Evaluation of an immunoblot assay for serological confirmation and differentiation of human T-cell lymphotropic virus types I and II.用于血清学确认和区分I型和II型人类嗜T细胞病毒的免疫印迹试验评估
J Clin Microbiol. 1993 Feb;31(2):260-4. doi: 10.1128/jcm.31.2.260-264.1993.
6
Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2.在纽约市1型和2型人类嗜T淋巴细胞病毒（HTLV）血清学阴性的献血者中检测HTLV tax序列。
Clin Diagn Lab Immunol. 2003 Jul;10(4):715-7. doi: 10.1128/cdli.10.4.715-717.2003.
7
Enhanced specificity of truncated transmembrane protein for serologic confirmation of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infections by western blot (immunoblot) assay containing recombinant envelope glycoproteins.通过含有重组包膜糖蛋白的蛋白质印迹法（免疫印迹法），截短跨膜蛋白对人嗜T细胞病毒1型（HTLV-1）和HTLV-2感染血清学确认的特异性增强。
J Clin Microbiol. 1995 Dec;33(12):3239-44. doi: 10.1128/jcm.33.12.3239-3244.1995.
8
Sensitivity of two enzyme-linked immunosorbent assay tests in relation to western blot in detecting human T-cell lymphotropic virus types I and II infection among HIV-1 infected patients from São Paulo, Brazil.在巴西圣保罗的HIV-1感染患者中，两种酶联免疫吸附试验检测人类嗜T细胞病毒I型和II型感染相对于免疫印迹法的敏感性。
Diagn Microbiol Infect Dis. 1998 Mar;30(3):173-82. doi: 10.1016/s0732-8893(97)00236-8.
9
Profile of the MP Diagnostics HTLV Blot 2.4 test: a supplemental assay for the confirmation and differentiation of antibodies to HTLV-1 and HTLV-2.MP诊断公司HTLV印迹2.4检测简介：一种用于确认和区分抗HTLV-1和HTLV-2抗体的补充检测方法。
Expert Rev Mol Diagn. 2016;16(2):135-45. doi: 10.1586/14737159.2016.1123622. Epub 2016 Jan 11.
10
Performances of HTLV serological tests in diagnosing HTLV infection in high-risk population of São Paulo, Brazil.巴西圣保罗高危人群中人类嗜T淋巴细胞病毒血清学检测在诊断人类嗜T淋巴细胞病毒感染中的表现。
Rev Inst Med Trop Sao Paulo. 2007 Nov-Dec;49(6):361-4. doi: 10.1590/s0036-46652007000600005.

本文引用的文献

1
Comparison of two new HTLV-I/II screening methods, Abbott Alinity i rHTLV-I/II and Diasorin LIAISON® XL murex recHTLV-I/II, to Abbott architect rHTLVI/II assay.比较两种新的 HTLV-I/II 筛选方法，雅培 Alinity i rHTLV-I/II 和 DiaSorin LIAISON XL murex recHTLV-I/II，与雅培 architect rHTLVI/II 检测方法。
J Clin Virol. 2023 Jul;164:105446. doi: 10.1016/j.jcv.2023.105446. Epub 2023 Apr 14.
2
A novel high performing multiplex immunoassay Multi-HTLV for serological confirmation and typing of HTLV infections.一种新型高通量免疫分析试剂盒 Multi-HTLV，用于 HTLV 感染的血清学确认和分型。
PLoS Negl Trop Dis. 2021 Nov 1;15(11):e0009925. doi: 10.1371/journal.pntd.0009925. eCollection 2021 Nov.
3
A Strategy for Screening and Confirmation of HTLV-1/2 Infections in Low-Endemic Areas.
低流行地区HTLV-1/2感染的筛查与确认策略
Front Microbiol. 2020 Jun 3;11:1151. doi: 10.3389/fmicb.2020.01151. eCollection 2020.
4
Seroprevalence of HTLV-1/2 Among Voluntary Blood Donors in Vietnam.越南无偿献血者中人类嗜T淋巴细胞病毒1型/2型的血清流行率
AIDS Res Hum Retroviruses. 2019 Apr;35(4):376-381. doi: 10.1089/AID.2018.0240. Epub 2019 Jan 29.
5
Reducing the global burden of HTLV-1 infection: An agenda for research and action.减轻人类嗜T淋巴细胞病毒1型（HTLV-1）感染的全球负担：研究与行动议程。
Antiviral Res. 2017 Jan;137:41-48. doi: 10.1016/j.antiviral.2016.10.015. Epub 2016 Nov 11.
6
Profile of the MP Diagnostics HTLV Blot 2.4 test: a supplemental assay for the confirmation and differentiation of antibodies to HTLV-1 and HTLV-2.MP诊断公司HTLV印迹2.4检测简介：一种用于确认和区分抗HTLV-1和HTLV-2抗体的补充检测方法。
Expert Rev Mol Diagn. 2016;16(2):135-45. doi: 10.1586/14737159.2016.1123622. Epub 2016 Jan 11.
7
Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters.在中非丛林肉猎人中出现独特的灵长类嗜T淋巴细胞病毒。
Proc Natl Acad Sci U S A. 2005 May 31;102(22):7994-9. doi: 10.1073/pnas.0501734102. Epub 2005 May 23.
8
Enhanced specificity of truncated transmembrane protein for serologic confirmation of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infections by western blot (immunoblot) assay containing recombinant envelope glycoproteins.通过含有重组包膜糖蛋白的蛋白质印迹法（免疫印迹法），截短跨膜蛋白对人嗜T细胞病毒1型（HTLV-1）和HTLV-2感染血清学确认的特异性增强。
J Clin Microbiol. 1995 Dec;33(12):3239-44. doi: 10.1128/jcm.33.12.3239-3244.1995.
9
A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia.一种与毛细胞白血病的T细胞变异型相关的人类T细胞白血病病毒（HTLV-II）新亚型。
Science. 1982 Nov 5;218(4572):571-3. doi: 10.1126/science.6981847.
10
Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood donors.美国献血者中人类嗜T淋巴细胞病毒I型（HTLV-I）感染的血清流行率及流行病学关联
Science. 1988 Apr 29;240(4852):643-6. doi: 10.1126/science.2896386.