Sabarinathan Devaraj, Sharma Arumugam Selva, Murugavelu Marimuthu, Kirubasankar Balakrishnan, Balusamy Indhiradevi, Han Zhang, Li Huanhuan, Chen Quansheng
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, PR China.
Athenese Dx Pvt Ltd, Chennai, Tamilnadu, India.
Heliyon. 2023 Apr 20;9(5):e15655. doi: 10.1016/j.heliyon.2023.e15655. eCollection 2023 May.
The development of nanoclusters based on incorporating biomolecules like proteins, lipids, enzymes, DNA, surfactants, and chemical stabilizers creates a stable and high fluorescence bio-sensors promising future due to their high sensitivity, high level of detection and better selectivity. This review addresses a comprehensive and systematic overview of the recent development in synthesizing metal nanocluster by various strategized synthesis techniques. Significantly, the application of nanometal clusters for the detection of various food contaminants such as microorganisms, antibodies, drugs, pesticides, metal contaminants, amino acids, and other food flavors have been discussed briefly concerning the detection techniques, sensitivity, selectivity, and lower limit of detection. The review further gives a brief account on the future prospects in the synthesis of novel metal nanocluster-based biosensors, and their advantages, shortcomings, and potential perspectives toward their application in the field of food safety analysis.
基于蛋白质、脂质、酶、DNA、表面活性剂和化学稳定剂等生物分子构建的纳米团簇，由于其高灵敏度、高检测水平和更好的选择性，为稳定且高荧光的生物传感器创造了光明的未来。本文综述了通过各种策略化合成技术合成金属纳米团簇的最新进展，进行了全面而系统的概述。值得注意的是，还简要讨论了纳米金属团簇在检测各种食品污染物方面的应用，如微生物、抗体、药物、农药、金属污染物、氨基酸和其他食品风味物质，涉及检测技术、灵敏度、选择性和检测下限。该综述还简要介绍了新型基于金属纳米团簇的生物传感器合成的未来前景，以及它们在食品安全分析领域应用的优点、缺点和潜在前景。
