Jarab Anan S, Al-Qerem Walid, Hamam Hanan, Abu Heshmeh Shrouq, Mukattash Tareq L, Alefishat Eman A
Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates.
Front Cardiovasc Med. 2023 Apr 19;10:1153310. doi: 10.3389/fcvm.2023.1153310. eCollection 2023.
Dyslipidemia is common among patients with heart failure, and it negatively impacts clinical outcomes. Limited data regarding the factors associated with poor lipid control in patients with HF patients. Therefore, this study aimed to evaluate lipid control and to explore the factors associated with poor lipid control in patients with HF.
The current cross-sectional study was conducted at outpatient cardiology clinics at two major hospitals in Jordan. Variables including socio-demographics, biomedical variables, in addition to disease and medication characteristics were collected using medical records and custom-designed questionnaire. Medication adherence was assessed using the validated 4-item Medication Adherence Scale. Binary logistic regression analysis was conducted to explore significant and independent predictors of poor lipid control among the study participants.
A total of 428 HF patients participated in the study. Results showed that 78% of the participants had poor lipid control. The predictors that were associated with poor lipid control included uncontrolled BP (OR = 0.552; 95% CI: 0.330-0.923; < 0.05), higher Hb levels (OR = 1.178; 95% CI: 1.013-1.369; < 0.05), and higher WBC (OR = 1.133; 95% CI: 1.031-1.246; < 0.05).
This study revealed poor lipid control among patients with HF. Future intervention programs should focus on blood pressure control in order to improve health outcomes among HF patients with dyslipidemia.
血脂异常在心力衰竭患者中很常见,并且对临床结局有负面影响。关于心力衰竭患者血脂控制不佳相关因素的数据有限。因此,本研究旨在评估心力衰竭患者的血脂控制情况,并探讨与血脂控制不佳相关的因素。
当前的横断面研究在约旦两家主要医院的门诊心脏病诊所进行。使用病历和定制问卷收集包括社会人口统计学、生物医学变量以及疾病和用药特征等变量。使用经过验证的4项用药依从性量表评估用药依从性。进行二元逻辑回归分析以探讨研究参与者中血脂控制不佳的显著和独立预测因素。
共有428名心力衰竭患者参与了该研究。结果显示,78%的参与者血脂控制不佳。与血脂控制不佳相关的预测因素包括血压未得到控制(OR = 0.552;95% CI:0.330 - 0.923;P < 0.05)、较高的血红蛋白水平(OR = 1.178;95% CI:1.013 - 1.369;P < 0.05)和较高的白细胞计数(OR = 1.133;95% CI:1.031 - 1.246;P < 0.05)。
本研究揭示了心力衰竭患者血脂控制不佳的情况。未来的干预项目应侧重于控制血压,以改善血脂异常的心力衰竭患者的健康结局。