骨关节炎中的间充质基质细胞：结构益处和软骨修复的证据
Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.
作者信息
Song Yujie, Jorgensen Christian
机构信息
IRMB, CARTIGEN, University of Montpellier, Inserm, CHU de Montpellier, 34090 Montpellier, France.
出版信息
Biomedicines. 2022 May 30;10(6):1278. doi: 10.3390/biomedicines10061278.
Abstract
Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists due to the lack of available drugs reducing structural degradation. Mesenchymal stromal cells (MSCs) may represent new therapeutic approaches in cartilage regeneration. In this review, we highlight the latest knowledge on the biological properties of MSC, such as their chondrogenic and immunomodulatory potential, and we give a brief overview of the effects of MSCs in preclinical and clinical studies of OA treatment and also compare different MSC sources, with the adipose tissue-derived MSCs being promising. Then, we focus on their structural benefit in treating OA and summarize the current evidence for the assessment of cartilage in OA according to magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy. Finally, this review provides a brief perspective on enhancing the activity of MSCs.
摘要
由于缺乏有效的减少结构退变的药物，骨关节炎（OA）给风湿病学家和骨科医生带来了重大的临床挑战。间充质基质细胞（MSCs）可能代表了软骨再生的新治疗方法。在这篇综述中，我们重点介绍了MSCs生物学特性的最新知识，例如它们的软骨生成和免疫调节潜能，简要概述了MSCs在OA治疗的临床前和临床研究中的作用，并比较了不同的MSCs来源，其中脂肪组织来源的MSCs很有前景。然后，我们关注它们在治疗OA方面的结构益处，并总结了目前根据磁共振成像（MRI）和MSCs治疗后二次关节镜检查评估OA中软骨的证据。最后，本综述简要展望了增强MSCs活性的方法。
相似文献
1
Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair.骨关节炎中的间充质基质细胞：结构益处和软骨修复的证据
Biomedicines. 2022 May 30;10(6):1278. doi: 10.3390/biomedicines10061278.
2
Mesenchymal stem cell sheet encapsulated cartilage debris provides great potential for cartilage defects repair in osteoarthritis.间质干细胞片包裹软骨碎片为骨关节炎的软骨缺损修复提供了巨大的潜力。
Med Hypotheses. 2012 Sep;79(3):420-1. doi: 10.1016/j.mehy.2012.05.024. Epub 2012 Jun 1.
3
Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Are More Effective Than Bone Marrow Aspiration Concentrate for Cartilage Regeneration After High Tibial Osteotomy in Medial Unicompartmental Osteoarthritis of Knee.同种异体人脐带血来源间充质干细胞在膝关节内侧单间室骨关节炎胫骨高位截骨术后软骨再生中比骨髓抽吸浓缩物更有效。
Arthroscopy. 2021 Aug;37(8):2521-2530. doi: 10.1016/j.arthro.2021.02.022. Epub 2021 Feb 20.
4
Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids Prevent Mesenchymal Stromal-Cell-Derived Chondrocyte Hypertrophy.基质细胞衍生 3 型微球体抑制基质细胞衍生软骨细胞肥大。
Int J Mol Sci. 2020 Nov 24;21(23):8911. doi: 10.3390/ijms21238911.
5
Mesenchymal Stromal Cell-Derived Extracellular Vesicles - Silver Linings for Cartilage Regeneration?间充质基质细胞衍生的细胞外囊泡——软骨再生的一线希望？
Front Cell Dev Biol. 2020 Dec 10;8:593386. doi: 10.3389/fcell.2020.593386. eCollection 2020.
6
Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow.滑膜来源的犬骨髓间充质干细胞比髌下脂肪垫、脂肪组织和骨髓来源的间充质干细胞具有更高的软骨形成潜力。
PLoS One. 2018 Aug 23;13(8):e0202922. doi: 10.1371/journal.pone.0202922. eCollection 2018.
7
Intra-articular Mesenchymal Stem Cells in Osteoarthritis of the Knee: A Systematic Review of Clinical Outcomes and Evidence of Cartilage Repair.关节内间充质干细胞治疗膝关节骨关节炎：临床结局的系统评价和软骨修复证据。
Arthroscopy. 2019 Jan;35(1):277-288.e2. doi: 10.1016/j.arthro.2018.07.028. Epub 2018 Nov 16.
8
Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes.异体脐带血源间充质基质细胞移植在软骨再生方面优于骨髓抽吸浓缩物增强，尽管临床结果相似。
Knee Surg Sports Traumatol Arthrosc. 2022 Jan;30(1):208-218. doi: 10.1007/s00167-021-06450-w. Epub 2021 Jan 25.
9
Amniotic Mesenchymal Stromal Cells Exhibit Preferential Osteogenic and Chondrogenic Differentiation and Enhanced Matrix Production Compared With Adipose Mesenchymal Stromal Cells.与脂肪间充质基质细胞相比，羊膜间充质基质细胞表现出优先的成骨和成软骨分化以及增强的基质产生。
Am J Sports Med. 2017 Sep;45(11):2637-2646. doi: 10.1177/0363546517706138. Epub 2017 May 25.
10
The lower in vitro chondrogenic potential of canine adipose tissue-derived mesenchymal stromal cells (MSC) compared to bone marrow-derived MSC is not improved by BMP-2 or BMP-6.与骨髓来源的间充质基质细胞（MSC）相比，犬脂肪组织来源的MSC较低的体外软骨形成潜能不会因骨形态发生蛋白-2（BMP-2）或骨形态发生蛋白-6（BMP-6）而得到改善。
Vet J. 2021 Mar;269:105605. doi: 10.1016/j.tvjl.2020.105605. Epub 2020 Dec 29.
引用本文的文献
1
Overview of Cellular Therapeutics Clinical Trials: Advances, Challenges, and Future Directions.细胞治疗临床试验概述：进展、挑战与未来方向。
Int J Mol Sci. 2025 Jun 16;26(12):5770. doi: 10.3390/ijms26125770.
2
Quality by design strategy of human mesenchymal stem/stromal cell drug products for the treatment of knee osteoarthritis.用于治疗膝关节骨关节炎的人间充质干/基质细胞药物产品的质量源于设计策略
World J Stem Cells. 2025 May 26;17(5):106547. doi: 10.4252/wjsc.v17.i5.106547.
3
Treatment outcomes for equine osteoarthritis with mesenchymal stromal cells and hyaluronic acid.间充质基质细胞和透明质酸治疗马骨关节炎的效果
Equine Vet J. 2025 Sep;57(5):1245-1254. doi: 10.1111/evj.14531. Epub 2025 May 13.
4
The Interaction Between Microbiota and Stem Cells on Progression of Osteoarthritis and Engineered Stem Cell for Enhancing Osteoarthritis Treatment.微生物群与干细胞在骨关节炎进展中的相互作用以及用于增强骨关节炎治疗的工程干细胞
Int J Nanomedicine. 2025 Mar 13;20:3219-3234. doi: 10.2147/IJN.S511884. eCollection 2025.
5
Efficacy and safety of mesenchymal stem cells in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.间充质干细胞治疗膝骨关节炎的疗效与安全性：一项随机对照试验的系统评价与Meta分析
Stem Cell Res Ther. 2025 Mar 7;16(1):122. doi: 10.1186/s13287-025-04252-2.
6
Bio-3D printing of scaffold-free ADSC-derived cartilage constructs comparable to natural cartilage in vitro.体外生物3D打印无支架的脂肪来源干细胞衍生软骨构建体，其性能与天然软骨相当。
J Orthop Surg Res. 2025 Feb 20;20(1):182. doi: 10.1186/s13018-025-05604-7.
7
Posterior iliac crest vs. proximal tibia: distinct sources of anti-inflammatory and regenerative cells with comparable 6-month clinical outcomes in treatment of osteoarthritis.髂后上棘与胫骨近端：治疗骨关节炎时，抗炎和再生细胞的不同来源，6个月临床疗效相当。
J Transl Med. 2024 Dec 4;22(1):1101. doi: 10.1186/s12967-024-05924-y.
8
Safety and efficacy of placental mesenchymal stromal cells-derived extracellular vesicles in knee osteoarthritis: a randomized, triple-blind, placebo-controlled clinical trial.胎盘间充质基质细胞衍生的细胞外囊泡治疗膝骨关节炎的安全性和有效性：一项随机、三盲、安慰剂对照临床试验。
BMC Musculoskelet Disord. 2024 Oct 28;25(1):856. doi: 10.1186/s12891-024-07979-w.
9
Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial.同种异体脂肪间充质干细胞制剂治疗膝骨关节炎的安全性和有效性：一项I/IIa期随机对照试验。
Osteoarthr Cartil Open. 2024 Jul 1;6(3):100500. doi: 10.1016/j.ocarto.2024.100500. eCollection 2024 Sep.
10
Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment.比较研究确定了间充质基质细胞在骨关节炎治疗中具有强大的再生活性。
NPJ Regen Med. 2024 Apr 1;9(1):14. doi: 10.1038/s41536-024-00358-y.
本文引用的文献
1
Human Umbilical Mesenchymal Stromal Cells Mixed with Hyaluronan Transplantation Decreased Cartilage Destruction in a Rabbit Osteoarthritis Model.人脐间充质基质细胞与透明质酸混合移植可减少兔骨关节炎模型中的软骨破坏。
Stem Cells Int. 2021 Oct 21;2021:2989054. doi: 10.1155/2021/2989054. eCollection 2021.
2
Intra-articular injection of human umbilical cord mesenchymal stem cells ameliorates monosodium iodoacetate-induced osteoarthritis in rats by inhibiting cartilage degradation and inflammation.关节腔内注射人脐带间充质干细胞通过抑制软骨降解和炎症反应改善大鼠碘乙酸钠诱导的骨关节炎。
Bone Joint Res. 2021 Mar;10(3):226-236. doi: 10.1302/2046-3758.103.BJR-2020-0206.R2.
3
Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review.髋关节和膝关节骨关节炎的诊断与治疗：综述
JAMA. 2021 Feb 9;325(6):568-578. doi: 10.1001/jama.2020.22171.
4
Two-step generation of mesenchymal stem/stromal cells from human pluripotent stem cells with reinforced efficacy upon osteoarthritis rabbits by HA hydrogel.通过透明质酸水凝胶从人多能干细胞两步生成间充质干/基质细胞，对骨关节炎兔的疗效增强。
Cell Biosci. 2021 Jan 6;11(1):6. doi: 10.1186/s13578-020-00516-x.
5
Mesenchymal stem cells - a promising strategy for treating knee osteoarthritis.间充质干细胞——治疗膝关节骨关节炎的一种有前景的策略。
Bone Joint Res. 2020 Oct;9(10):719-728. doi: 10.1302/2046-3758.910.BJR-2020-0031.R3.
6
Metabolic osteoarthritis - relation of diabetes and cardiovascular disease with knee osteoarthritis.代谢性骨关节炎-糖尿病和心血管疾病与膝骨关节炎的关系。
Osteoarthritis Cartilage. 2021 Feb;29(2):230-234. doi: 10.1016/j.joca.2020.09.010. Epub 2020 Nov 27.
7
Physioxia Expanded Bone Marrow Derived Mesenchymal Stem Cells Have Improved Cartilage Repair in an Early Osteoarthritic Focal Defect Model.物理缺氧扩增的骨髓间充质干细胞在早期骨关节炎局灶性缺损模型中改善了软骨修复。
Biology (Basel). 2020 Aug 17;9(8):230. doi: 10.3390/biology9080230.
8
Adipose Tissue-Derived Stem Cells: The Biologic Basis and Future Directions for Tissue Engineering.脂肪组织来源的干细胞：组织工程的生物学基础及未来方向
Materials (Basel). 2020 Jul 18;13(14):3210. doi: 10.3390/ma13143210.
9
Intra-articular delivery of umbilical cord-derived mesenchymal stem cells temporarily retard the progression of osteoarthritis in a rat model.关节内注射脐带间充质干细胞可暂时延缓骨关节炎在大鼠模型中的进展。
Int J Rheum Dis. 2020 Jun;23(6):778-787. doi: 10.1111/1756-185X.13834. Epub 2020 Apr 21.
10
Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration.人脂肪来源干细胞分泌的小细胞外囊泡可减轻软骨退变。
J Extracell Vesicles. 2020 Mar 9;9(1):1735249. doi: 10.1080/20013078.2020.1735249. eCollection 2020.
Zotero 插件