一篇关于经临床验证的天然产物在神经痛管理中的综合综述，并附有机制见解。
A comprehensive review on clinically proven natural products in the management of nerve pain, with mechanistic insights.
作者信息
Dewanjee Sanchita, Sohel Md, Hossain Md Shahadat, Ansari Farzana, Islam Md Tofikul, Sultana Farhana, Al Mamun Abdullah, Islam Md Monirul, Amin Mohammad Nurul
机构信息
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh.
Department of Biochemistry and Molecular Biology, Primeasia University, Banani, Dhaka, 1213, Bangladesh.
出版信息
Heliyon. 2023 Apr 14;9(5):e15346. doi: 10.1016/j.heliyon.2023.e15346. eCollection 2023 May.
INTRODUCTION
People are treating their neuropathic pain with several approved and licensed pharmacological drugs. But due to having existing limitations like low efficacy with some side effects, there needs to be a more effective alternative and complementary therapeutic options.
PURPOSE
s: The study was designed to discuss the mechanistic role of several clinically proven natural products that have been shown to play a significant role against different nerve pain or neuropathic pain.
METHOD
ology: Information for this review article was salvaged using several accessible searching databases like SciVerse Scopus ® (Elsevier Properties S. A, USA), Web of Science® (Thomson Reuters, USA), and PubMed® (U.S. National Library of Medicine, USA) considering some search items like - nerve pain, natural products in pain/nerve pain management, clinically proven natural products in pain management, pain-reducing agents and so on.
RESULT
Our study reported the therapeutic efficacy of natural products and their possible mechanism against neuropathic pain in the human body. Natural products widely used to treat neuropathic pain include comfrey root extract ointment, lavender oil, Rose Oil, aromatic essential oil, ginger oil, vitex agnus-castus, peganum oil, and ajwain 10%. Some common pathways are involved in pain relief through sensory stimulation, enzymatic, anti-inflammatory, and pain-related receptor regulation.
CONCLUSION
The present study suggests that the mentioned natural products can be an appropriate choice for the treatment and management of neuropathic pain.
引言
人们正在使用几种已获批准和许可的药物来治疗神经性疼痛。但由于存在诸如疗效低且有一些副作用等现有局限性，因此需要更有效的替代和补充治疗选择。
目的
本研究旨在探讨几种临床验证的天然产物的作用机制，这些天然产物已被证明在对抗不同的神经疼痛或神经性疼痛方面发挥着重要作用。
方法
本综述文章的信息是通过使用几个可访问的搜索数据库获取的，如SciVerse Scopus®（美国爱思唯尔出版社）、Web of Science®（美国汤森路透公司）和PubMed®（美国国立医学图书馆），考虑了一些搜索词，如神经疼痛、疼痛/神经疼痛管理中的天然产物、疼痛管理中临床验证的天然产物、止痛剂等。
结果
我们的研究报告了天然产物在人体中对抗神经性疼痛的治疗效果及其可能的机制。广泛用于治疗神经性疼痛的天然产物包括紫草根提取物软膏、薰衣草油、玫瑰油、芳香精油、姜油、贞节树、骆驼蓬油和10%的阿育吠陀。一些常见的途径涉及通过感觉刺激、酶促、抗炎和疼痛相关受体调节来缓解疼痛。
结论
本研究表明，上述天然产物可以是治疗和管理神经性疼痛的合适选择。
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