香叶天竺葵和穗花牡荆精油的抗菌活性及成分
Antibacterial activity and composition of essential oils from Pelargonium graveolens L'Her and Vitex agnus-castus L.
作者信息
Ghannadi A, Bagherinejad Mr, Abedi D, Jalali M, Absalan B, Sadeghi N
机构信息
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Iran J Microbiol. 2012 Dec;4(4):171-6.
BACKGROUND AND OBJECTIVES
Essential oils are volatile compounds that have been used since Middle Ages as antimicrobial, anti-inflammatory, sedative, local anesthetic and food flavoring agents. In the current study, essential oils of Pelargonium graveolens L'Her and Vitex agnus-castus L. were analyzed for their antibacterial activities.
MATERIALS AND METHODS
The chemical compositions of essential oils were characterized by GC-MS. Disc diffusion method was used to study antimicrobial activity.
RESULTS AND CONCLUSION
Inhibition zones showed that the essential oils of the two plants were active against all of the studied bacteria (except Listeria monocytogenes). The susceptibility of the strains changed with the dilution of essential oils in DMSO. The pure essential oils showed the most extensive inhibition zones and they were very effective antimicrobial compounds compared to chloramphenicol and amoxicillin. The most susceptible strain against these two essential oils was Staphylococcus aureus. It seems that β-citronellol is a prominent part of P. graveolens volatile oil and caryophyllene oxide is a famous and important part of V. agnus-castus volatile oil and their probable synergistic effect with other constituents are responsible for the antibacterial effects of these oils. However further studies must be performed to confirm the safety of these oils for use as antimicrobial agents and natural preservatives in different products.
背景与目的
精油是挥发性化合物，自中世纪以来就被用作抗菌、抗炎、镇静、局部麻醉和食品调味剂。在本研究中，对香叶天竺葵和穗花牡荆的精油进行了抗菌活性分析。
材料与方法
通过气相色谱 - 质谱联用（GC - MS）对精油的化学成分进行表征。采用纸片扩散法研究抗菌活性。
结果与结论
抑菌圈表明这两种植物的精油对所有研究的细菌（单核细胞增生李斯特菌除外）均有活性。菌株的敏感性随精油在二甲基亚砜中的稀释而变化。纯精油显示出最广泛的抑菌圈，与氯霉素和阿莫西林相比，它们是非常有效的抗菌化合物。对这两种精油最敏感的菌株是金黄色葡萄球菌。似乎β - 香茅醇是香叶天竺葵挥发油的主要成分，氧化石竹烯是穗花牡荆挥发油的著名且重要的成分，它们与其他成分可能的协同作用导致了这些精油的抗菌效果。然而，必须进行进一步的研究以确认这些精油在不同产品中用作抗菌剂和天然防腐剂的安全性。
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