Department of Biophysics, Medicine Faculty, Ondokuz Mayis University, Samsun, Turkey.
Physiol Res. 2023 Apr 30;72(2):187-198. doi: 10.33549/physiolres.935024.
We aimed to investigate the effects of melatonin and resveratrol on diabetes-related papillary muscle dysfunction and structural heart disorders. The protective effect of resveratrol and melatonin supplementation on cardiac functions was investigated in a diabetic elderly female rat model. 16-month-old rats (n=48) were allocated into 8 groups. Group1: Control, Group2: Resveratrol Control, Group3: Melatonin Control, Group4: Resveratrol and Melatonin Control, Group5: Diabetes, Group6: Diabetes Resveratrol, Group7: Diabetes Melatonin, Group8: Diabetes Resveratrol and Melatonin. Streptozotocin was injected intraperitoneally to the rats for experimental diabetes induction. Thereafter, resveratrol (intraperitoneal) and melatonin (subcutaneous) were administered for 4 weeks. Resveratrol and melatonin had a protective effect on the contractile parameters and structural properties of the papillary muscle, which was impaired by diabetes. it has been presented that diabetes impairs the contractile function of the papillary muscle for each stimulus frequency tested and the responses obtained as a result of Ca+2 uptake and release mechanisms from the Sarcoplasmic reticulum, and it has been observed that these effects are improved with resveratrol and melatonin injection. The decrease in myocardial papillary muscle strength in the diabetic elderly female rat can be reversed with the combination of resveratrol, melatonin and resveratrol+melatonin. Melatonin+resveratrol supplementation is no different from melatonin and/or resveratrol supplementation. Resveratrol and melatonin supplementation may have a protective effect on cardiac functions in a diabetic elderly female rat model.
我们旨在研究褪黑素和白藜芦醇对糖尿病相关乳头肌功能障碍和结构性心脏疾病的影响。在糖尿病老年雌性大鼠模型中，研究了白藜芦醇和褪黑素补充对心脏功能的保护作用。将 16 个月大的大鼠（n=48）分为 8 组。第 1 组：对照组；第 2 组：白藜芦醇对照组；第 3 组：褪黑素对照组；第 4 组：白藜芦醇和褪黑素对照组；第 5 组：糖尿病组；第 6 组：糖尿病白藜芦醇组；第 7 组：糖尿病褪黑素组；第 8 组：糖尿病白藜芦醇和褪黑素组。向大鼠腹腔内注射链脲佐菌素以诱导实验性糖尿病。之后，给予白藜芦醇（腹腔内）和褪黑素（皮下）4 周。白藜芦醇和褪黑素对糖尿病引起的乳头肌收缩参数和结构特性具有保护作用，糖尿病损害了乳头肌对每种刺激频率的收缩功能，以及通过肌浆网从肌浆网摄取和释放 Ca+2 的机制获得的反应，并且观察到这些作用随着白藜芦醇和褪黑素的注射而改善。糖尿病老年雌性大鼠心肌乳头肌强度下降可通过白藜芦醇、褪黑素和白藜芦醇+褪黑素的联合作用逆转。褪黑素+白藜芦醇补充与褪黑素和/或白藜芦醇补充没有区别。褪黑素和白藜芦醇补充可能对糖尿病老年雌性大鼠模型的心脏功能具有保护作用。
