Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
Effective Care Research Units, Department of Obstetrics and Gynaecology, Nnamdi, Azikiwe University, Nnewi Campus, Nigeria.
J Int Med Res. 2023 May;51(5):3000605231171489. doi: 10.1177/03000605231171489.
To determine the efficacy of zinc sulfate supplementation in managing dysmenorrhoea.
In total, 103 high school students were randomised into an experimental arm (52 students) and a control arm (51 students) and received 40-mg zinc sulfate or placebo, respectively, over three cycles. Primary outcome measures were the mean Visual Analogue Scale score, which measured pain over three cycles, and the frequency of nausea and vomiting. Secondary outcomes were the use of additional analgesics and the frequency of allergic reactions.
Fifty participants were analysed in each group. Mean pain scores were not significantly different between the groups before administering zinc sulfate therapy. Following the intervention, the mean pain scores for the treatment (2.80 ± 2.28) and placebo (3.48 ± 2.85) groups were not significantly different in the first cycle; however, scores in the treatment group were significantly better in the second (2.56 ± 1.97 vs 3.80 ± 2.77) and third (1.95 ± 1.72 vs 3.95 ± 2.82) cycles. No significant differences were observed between the groups in the nausea and vomiting incidence and the requirement for additional analgesics.
Zinc sulfate reduces dysmenorrhoea severity with minimal or no adverse effects, especially with more than one cycle of usage.Trial Registration Number: PACTR202105843292338. The trial is publicly available and was registered at www.pactr.org on 25 May 2021.
评估硫酸锌补充剂治疗痛经的疗效。
共有 103 名高中生被随机分为实验组（52 名学生）和对照组（51 名学生），分别在三个周期内服用 40mg 硫酸锌或安慰剂。主要结局指标为三个周期内平均视觉模拟评分（VAS），用于衡量疼痛程度，以及恶心和呕吐的频率。次要结局指标为额外使用镇痛药的频率和过敏反应的频率。
每组各有 50 名参与者纳入分析。在给予硫酸锌治疗前，两组的平均疼痛评分无显著差异。干预后，治疗组（2.80±2.28）和对照组（3.48±2.85）在第一周期的平均疼痛评分无显著差异；然而，在第二周期（2.56±1.97 比 3.80±2.77）和第三周期（1.95±1.72 比 3.95±2.82），治疗组的评分明显更好。两组在恶心和呕吐发生率以及对额外镇痛药的需求方面无显著差异。
硫酸锌可减轻痛经严重程度，且副作用最小或无，特别是在使用超过一个周期时。
PACTR202105843292338。该试验可公开获取，于 2021 年 5 月 25 日在 pactr.org 注册。
