Martín-Pérez Alberto, Ramos Daniel
Optomechanics Lab, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), 3 Sor Juana Inés de la Cruz (Madrid), E-28049 Madrid, Spain.
Microsyst Nanoeng. 2023 May 8;9:53. doi: 10.1038/s41378-023-00531-1. eCollection 2023.
Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic forces. However, there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing particle. In this work, we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators (SMRs). This hydrodynamic force sensitivity depends on the device used; therefore, we considered the geometry and materials to advance this dependency on the SMR resonance frequency.
微流控技术在分析流动颗粒方面展现出了高度的通用性，甚至可以通过施加流体动力来实现对生物细胞机械性能的测量。然而，目前尚无能够直接测量和跟踪作用于流动颗粒上的这些流体动力的技术。在这项工作中，我们基于对悬浮微通道谐振器（SMR）诱导共振变化的分析，引入了一种直接测量作用于流动颗粒上的流体动力的新方法。这种流体动力灵敏度取决于所使用的器件；因此，我们考虑了几何形状和材料，以提升这种对SMR共振频率的依赖性。
