Bionanomechanics Lab, Instituto de Micro y Nanotecnología, IMN-CNM (CSIC), Isaac Newton 8 (PTM), E-28760 Tres Cantos, Madrid, Spain.
Sensors (Basel). 2019 Nov 20;19(23):5069. doi: 10.3390/s19235069.
Characterization of micro and nanoparticle mass has become increasingly relevant in a wide range of fields, from materials science to drug development. The real-time analysis of complex mixtures in liquids demands very high mass sensitivity and high throughput. One of the most promising approaches for real-time measurements in liquid, with an excellent mass sensitivity, is the use of suspended microchannel resonators, where a carrier liquid containing the analytes flows through a nanomechanical resonator while tracking its resonance frequency shift. To this end, an extremely sensitive mechanical displacement technique is necessary. Here, we have developed an optomechanical transduction technique to enhance the mechanical displacement sensitivity of optically transparent hollow nanomechanical resonators. The capillaries have been fabricated by using a thermal stretching technique, which allows to accurately control the final dimensions of the device. We have experimentally demonstrated the light coupling into the fused silica capillary walls and how the evanescent light coming out from the silica interferes with the surrounding electromagnetic field distribution, a standing wave sustained by the incident laser and the reflected power from the substrate, modulating the reflectivity. The enhancement of the displacement sensitivity due to this interferometric modulation (two orders of magnitude better than compared with previous accomplishments) has been theoretically predicted and experimentally demonstrated.
微粒和纳米粒子质量的描述在从材料科学到药物开发的广泛领域变得越来越重要。对液体中复杂混合物的实时分析需要非常高的质量灵敏度和高通量。在液体中进行实时测量的最有前途的方法之一是使用悬浮微通道谐振器,其中含有分析物的载液流过纳米机械谐振器,同时跟踪其共振频率的移动。为此,需要一种极其灵敏的机械位移技术。在这里,我们开发了一种光机械转换技术,以提高光学透明空心纳米机械谐振器的机械位移灵敏度。通过使用热拉伸技术制造了毛细管,这使得可以精确控制器件的最终尺寸。我们已经实验证明了光耦合到熔融石英毛细管壁中,以及从石英逸出的消逝光如何与周围的电磁场分布相互作用,由入射激光和从基底反射的光维持的驻波,调制反射率。由于这种干涉调制(比以前的成就提高了两个数量级)引起的位移灵敏度增强已经在理论上进行了预测并在实验中得到了证明。