Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.
National Key Laboratory of Medical Immunology &Institute of immunology, Navy Medical University, Shanghai, 200433, P. R. China.
Angew Chem Int Ed Engl. 2023 Jul 17;62(29):e202302723. doi: 10.1002/anie.202302723. Epub 2023 Jun 7.
The emulation of functions and behaviors of biological synapses using electronic devices has inspired the development of artificial neural networks (ANNs) in biomedical interfaces. Despite the achievements, artificial synapses that can be selectively responsive to non-electroactive biomolecules and directly operate in biological environments are still lacking. Herein, we report an artificial synapse based on organic electrochemical transistors and investigate the selective modulation of its synaptic plasticity by glucose. The enzymatic reaction between glucose and glucose oxidase results in long-term modulation of the channel conductance, mimicking selective binding of biomolecules to their receptors and consequent long-term modulation of the synaptic weight. Moreover, the device shows enhanced synaptic behaviors in the blood serum at a higher glucose concentration, which suggests its potential application in vivo as artificial neurons. This work provides a step towards the fabrication of ANNs with synaptic plasticity selectively mediated by biomolecules for neuro-prosthetics and human-machine interfaces.
使用电子设备模拟生物突触的功能和行为，启发了生物医学接口中人工神经网络 (ANNs) 的发展。尽管已经取得了一些成果，但仍然缺乏能够选择性响应非电活性生物分子并直接在生物环境中运行的人工突触。在这里，我们报告了一种基于有机电化学晶体管的人工突触，并研究了其对葡萄糖的突触可塑性的选择性调制。葡萄糖和葡萄糖氧化酶之间的酶反应导致通道电导的长期调制，模拟生物分子与其受体的选择性结合以及随后的突触权重的长期调制。此外，该器件在较高葡萄糖浓度的血清中表现出增强的突触行为，这表明其在体内作为人工神经元的潜在应用。这项工作朝着制造具有生物分子选择性介导的突触可塑性的 ANN 迈出了一步，可用于神经修复和人机接口。
