三七（Panax notoginseng (Burk.) F. H. Chen）根中的达玛烷型三萜皂苷及其神经保护作用。

Dammarane-type triterpene saponins from the roots of Panax notoginseng (Burk.) F. H. Chen and their neuroprotective effects.

机构信息

College of Food Science and Pharmacology, Xinjiang Agricultural University, Urumqi 830052, China; School of Life Sciences, Huaiyin Normal University, Huaian 223300, China.

School of Life Sciences, Huaiyin Normal University, Huaian 223300, China.

出版信息

Fitoterapia. 2023 Jul;168:105541. doi: 10.1016/j.fitote.2023.105541. Epub 2023 May 11.

DOI:10.1016/j.fitote.2023.105541

PMID:37178809

Abstract

Three undescribed dammarane-type triterpene saponins, 20(S)-sanchirhinoside A-A (1-3), together with seventeen known ones, were isolated from the roots of Panax notoginseng (Burk.) F. H. Chen. The chemical structures of the new compounds were determined by HR-MS and NMR experiments along with chemical methods. To the best of our knowledge, compound 1 was the firstly reported fucose-containing triterpene saponin from plants in the genus of Panax. Moreover, the in vitro neuroprotective effects of the isolated compounds were evaluated. Compounds 11-12 displayed remarkable protective effects against PC12 cells injured by 6-hydroxydopamine.

摘要

从三七（Panax notoginseng (Burk.) F. H. Chen）的根部分离得到三种未被描述的达玛烷型三萜皂苷，20(S)-桑奇苷 A-A（1-3），以及十七种已知化合物。通过高分辨质谱和 NMR 实验以及化学方法确定了新化合物的化学结构。据我们所知，化合物 1 是首次从植物属中报道的含有岩藻糖的三萜皂苷。此外，还评估了分离化合物的体外神经保护作用。化合物 11-12 对 6-羟多巴胺损伤的 PC12 细胞表现出显著的保护作用。