Zhang Hongliang, Zhao Saisai, Zhang Haojie, Qin Zhihua, Shan Hu, Cai Xiulei
Shandong Collaborative Innovation Center for Development of Veterinary Pharmaceuticals, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Front Microbiol. 2023 Apr 27;14:1139494. doi: 10.3389/fmicb.2023.1139494. eCollection 2023.
African swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH). The economic losses to the global pig industry have been insurmountable since the outbreak of ASF. Control and eradication of ASF are very critical during the current pandemic. Vaccination is the optimal strategy to prevent and control the ASF epidemic, but since inactivated ASFV vaccines have poor immune protection and there aren't enough cell lines for efficient ASFV replication, an ASF vaccine with high immunoprotective potential still remains to be explored. Knowledge of the course of disease evolution, the way of virus transmission, and the breakthrough point of vaccine design will facilitate the development of an ASF vaccine. In this review, the paper aims to highlight the recent advances and breakthroughs in the epidemic and transmission of ASF, virus mutation, and the development of vaccines in recent years, focusing on future directions and trends.
非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）引起的猪的一种致命性传染病。目前，该疾病被列为须向世界动物卫生组织（WOAH）报告的法定应报告疾病。自ASF爆发以来，全球养猪业遭受了难以估量的经济损失。在当前疫情期间，控制和根除ASF至关重要。疫苗接种是预防和控制ASF疫情的最佳策略，但由于灭活ASFV疫苗的免疫保护效果不佳，且缺乏足够用于高效ASFV复制的细胞系，具有高免疫保护潜力的ASF疫苗仍有待探索。了解疾病演变过程、病毒传播方式以及疫苗设计的突破点将有助于ASF疫苗的研发。在这篇综述中，本文旨在突出近年来ASF在流行和传播、病毒变异以及疫苗研发方面的最新进展和突破，重点关注未来方向和趋势。
