Wu Keke, Liu Jiameng, Wang Lianxiang, Fan Shuangqi, Li Zhaoyao, Li Yuwan, Yi Lin, Ding Hongxing, Zhao Mingqiu, Chen Jinding
College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Vaccines (Basel). 2020 Sep 15;8(3):531. doi: 10.3390/vaccines8030531.
African swine fever (ASF) is a highly lethal contagious disease of swine caused by African swine fever virus (ASFV). At present, it is listed as a notifiable disease reported to the World Organization for Animal Health (OIE) and a class one animal disease ruled by Chinese government. ASF has brought significant economic losses to the pig industry since its outbreak in China in August 2018. In this review, we recapitulated the epidemic situation of ASF in China as of July 2020 and analyzed the influencing factors during its transmission. Since the situation facing the prevention, control, and eradication of ASF in China is not optimistic, safe and effective vaccines are urgently needed. In light of the continuous development of ASF vaccines in the world, the current scenarios and evolving trends of ASF vaccines are emphatically analyzed in the latter part of the review. The latest research outcomes showed that attempts on ASF gene-deleted vaccines and virus-vectored vaccines have proven to provide complete homologous protection with promising efficacy. Moreover, gaps and future research directions of ASF vaccine are also discussed.
非洲猪瘟（ASF）是一种由非洲猪瘟病毒（ASFV）引起的猪的高致死性传染病。目前，它被列为向世界动物卫生组织（OIE）报告的须通报疾病，也是中国政府规定的一类动物疫病。自2018年8月在中国爆发以来，非洲猪瘟给养猪业带来了巨大的经济损失。在本综述中，我们总结了截至2020年7月中国非洲猪瘟的疫情情况，并分析了其传播过程中的影响因素。鉴于中国非洲猪瘟的预防、控制和根除形势不容乐观，迫切需要安全有效的疫苗。鉴于世界上非洲猪瘟疫苗的不断发展，本综述的后半部分着重分析了非洲猪瘟疫苗的当前情况和发展趋势。最新研究成果表明，非洲猪瘟基因缺失疫苗和病毒载体疫苗的尝试已证明能提供完全的同源保护，效果良好。此外，还讨论了非洲猪瘟疫苗的差距和未来研究方向。
