Perbellini L, Brugnone F, Cocheo V, De Rosa E, Bartolucci G B
Arch Toxicol. 1986 Apr;58(4):229-34. doi: 10.1007/BF00297111.
Numerous n-heptane metabolites have been identified and quantified by gas chromatography and mass spectrometry in some tissues and in the urine of Sprague Dawley rats exposed for 6 h to 1800 ppm n-heptane. 2-Heptanol and 3-heptanol were the main biotransformation products of the solvent. 2-Heptanone, 3-heptanone, 4-heptanol, 2,5-heptanedione, gamma-valerolactone, 2-ethyl-5-methyl-2,3-dihydrofuran and 2,6-dimethyl-2,5-dihydropyran were also found as metabolites of n-heptane. In five shoe factory workers and in three rubber factory workers the mean exposure to technical heptane was measured (n-heptane ranged between 5 and 196 mg/m3). In the urine collected at the end of their work shift some n-heptane biotransformation products were found: 2-heptanol, 3-heptanol, 2-heptanone, 4-heptanone and 2,5-heptanedione. 2-Heptanol was the main n-heptane metabolite and its urinary concentrations ranged between 0.1 and 1.9 mg/l. Urinary 2,5-heptanedione was detectable only in some samples and at very low concentration (0.1-0.4 mg/l). These data suggest that n-heptane can be considered as a neurotoxic product, since it gives rise to 2,5-heptanedione, but the small amount of the urinary metabolite is very unlikely to cause clinical damage to the peripheral nervous system.
通过气相色谱法和质谱法，已在暴露于1800 ppm正庚烷6小时的斯普拉格-道利大鼠的某些组织和尿液中鉴定并定量了多种正庚烷代谢物。2-庚醇和3-庚醇是该溶剂的主要生物转化产物。还发现2-庚酮、3-庚酮、4-庚醇、2,5-庚二酮、γ-戊内酯、2-乙基-5-甲基-2,3-二氢呋喃和2,6-二甲基-2,5-二氢吡喃是正庚烷的代谢物。在五名鞋厂工人和三名橡胶厂工人中测量了他们对工业庚烷的平均暴露量（正庚烷含量在5至196 mg/m³之间）。在他们轮班结束时收集的尿液中发现了一些正庚烷生物转化产物：2-庚醇、3-庚醇、2-庚酮、4-庚酮和2,5-庚二酮。2-庚醇是主要的正庚烷代谢物，其尿液浓度在0.1至1.9 mg/l之间。尿中的2,5-庚二酮仅在一些样品中可检测到，且浓度非常低（0.1 - 0.4 mg/l）。这些数据表明正庚烷可被视为一种神经毒性产物，因为它会产生2,5-庚二酮，但尿中代谢物的量很少，极不可能对周围神经系统造成临床损害。
