Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Faculty of Medicine, Institute of Anatomy, Musculoskeletal & Tumor Biology Research Group, Ludwig-Maximilians-University Munich, Munich, Germany.
Diabetes Metab Res Rev. 2024 Feb;40(2):e3655. doi: 10.1002/dmrr.3655. Epub 2023 May 14.
Dysbiosis or imbalance of microbes in the gut has been associated with susceptibility and progression of type 1 diabetes mellitus (T1DM). The present systematic review and meta-analysis examined the effects of probiotics, prebiotics, and synbiotics on fasting blood glucose (FBG), haemoglobin A1c (HbA1c), C-peptide, and insulin requirements in T1DM patients. A systematic search for trials published up to October 2022 was conducted in PubMed, EMBASE, Scopus, Google Scholar, ScienceDirect, Web of Science, and the Central Cochrane Library. Random effect models were used to synthesise quantitative data by STATA . After the evaluation of 258 identified entries, five randomised controlled trials (n = 356; mean age = 11.7 years old) were included. The pooled effect size showed that FBG decreased following probiotic supplementation (weighted mean difference = -31.24 mg/dL; 95% confidence interval = -45.65, -16.83; p < 0.001), however, there was no significant improvement in serum HbA1c, C-peptide, and insulin requirements. Probiotic supplementation could be a complementary therapeutic strategy in T1DM. The evidence is limited; therefore, it is crucial to conduct more trials.
肠道微生物失调或失衡与 1 型糖尿病（T1DM）的易感性和进展有关。本系统评价和荟萃分析检查了益生菌、益生元和合生菌对 T1DM 患者空腹血糖（FBG）、糖化血红蛋白（HbA1c）、C 肽和胰岛素需求的影响。在 PubMed、EMBASE、Scopus、Google Scholar、ScienceDirect、Web of Science 和 Cochrane 中心图书馆中对截至 2022 年 10 月发表的试验进行了系统搜索。使用 STATA 对定量数据进行了随机效应模型合成。在评估了 258 个已确定的条目后，纳入了五项随机对照试验（n=356；平均年龄=11.7 岁）。汇总效应大小表明，益生菌补充后 FBG 下降（加权均数差=-31.24mg/dL；95%置信区间=-45.65，-16.83；p<0.001），但血清 HbA1c、C 肽和胰岛素需求没有显著改善。益生菌补充可能是 T1DM 的一种补充治疗策略。证据有限；因此，开展更多试验至关重要。
