Kim Y, Miller K, Michael A F
J Lab Clin Med. 1977 Apr;89(4):845-50.
Serum concentrations of Clq, C4, C3, and Factor B but not properdin were significantly decreased in patients with HUS compared to values in normal control subjects (p value less than 0.01). Sera from 13 HUS patients obtained early after the onset of the disease showed breakdown products of Factor B (Ba, Bb) by immunoelectrophoresis; 12 of these sera showed C3 breakdown products (C3c, C3d). Sera from seven patients studied 1 month to 3 years later no longer demonstrated any breakdown products of Factor B or C3. These data suggest that the complemented system is activate in HUS. The concept that immunological mechanisms play a major role in this disease is additionally supported by the occurrence of IgM, C3, and fibrin in glomeruli and renal vessels.
与正常对照受试者相比，溶血尿毒综合征（HUS）患者血清中Clq、C4、C3和B因子的浓度显著降低，但备解素浓度无显著变化（p值小于0.01）。13例HUS患者在疾病发作后早期采集的血清经免疫电泳显示有B因子的裂解产物（Ba、Bb）；其中12份血清显示有C3裂解产物（C3c、C3d）。对7例患者在1个月至3年后进行研究，其血清不再显示B因子或C3的任何裂解产物。这些数据表明补体系统在HUS中被激活。肾小球和肾血管中出现IgM、C3和纤维蛋白，进一步支持了免疫机制在该疾病中起主要作用的观点。
