May J E, Frank M M
Proc Natl Acad Sci U S A. 1973 Mar;70(3):649-52. doi: 10.1073/pnas.70.3.649.
A new cytolytic pathway is described whereby cells sensitized with cytotoxic antibody can be specifically lysed in the complete absence of intact, classical complement pathway function. Evaluation of this model with sera deficient in the 4th (C4), 2nd (C2), and 6th (C6) components of complement has revealed that this new lytic mechanism, termed the C1-bypass activation pathway, is initiated by the antibody-mediated activation of C1. Utilizing components of the previously described alternate complement pathway, this pathway bypasses C4 and C2 to activate the third to ninth components of complement (C3-9) with induction of membrane damage.
描述了一种新的细胞溶解途径，通过该途径，用细胞毒性抗体致敏的细胞在完全缺乏完整的经典补体途径功能的情况下能够被特异性裂解。用缺乏补体第四（C4）、第二（C2）和第六（C6）成分的血清对该模型进行评估后发现，这种新的溶解机制，称为C1旁路激活途径，由抗体介导的C1激活引发。利用先前描述的替代补体途径的成分，该途径绕过C4和C2来激活补体的第三至第九成分（C3-9），并诱导膜损伤。
