Peart G F, Boutagy J, Shenfield G M
Br J Clin Pharmacol. 1986 May;21(5):465-71. doi: 10.1111/j.1365-2125.1986.tb02827.x.
The standard laboratory method for determination of debrisoquine phenotype has been modified and shortened with no loss of sensitivity. Debrisoquine metabolic ratios (MR) at 4 and 8 h showed excellent correlation indicating that collection time can also be shortened. Same day phenotyping is therefore possible. One hundred normal, Caucasian Australian subjects were phenotyped (46 males, 54 females) and 6% were poor metabolisers (PM) of debrisoquine. Fifty of the original subjects were also acetylation phenotyped and 34% were fast and 66% slow acetylators. One PM of debrisoquine was a fast acetylator of sulphadimidine and four PM were slow acetylators. This was a non-significant association.
用于确定异喹胍代谢表型的标准实验室方法已得到改进和简化，且灵敏度未受损失。4小时和8小时时的异喹胍代谢率（MR）显示出极佳的相关性，这表明采集时间也可以缩短。因此，同一天进行表型分析是可行的。对100名澳大利亚白种人正常受试者进行了表型分析（46名男性，54名女性），其中6%为异喹胍慢代谢者（PM）。对最初的50名受试者也进行了乙酰化表型分析，其中34%为快乙酰化者，66%为慢乙酰化者。一名异喹胍PM是磺胺二甲嘧啶的快乙酰化者，四名PM是慢乙酰化者。这是一种无显著意义的关联。
