Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11823, Egypt.
Funct Integr Genomics. 2024 Nov 7;24(6):209. doi: 10.1007/s10142-024-01476-y.
Breast cancer (BC) occupies the top spot among women on a global scale. The tumor has a significant degree of heterogeneity, displaying a notable prevalence of medication resistance, recurrence, and metastasis, rendering it one of the most lethal forms of malignant neoplasms. The timely identification, ongoing evaluation of therapeutic interventions, and accurate prediction of outcomes play crucial roles in determining the overall survival rates of women with BC. Nevertheless, the absence of precise biomarkers remains a significant determinant impacting the overall well-being and both the physical and emotional health of BC patients. Long noncoding RNA (lncRNA) exerts regulatory control over several genes and signaling pathways, hence assuming crucial roles in the development of neoplastic growth. Recently, research has indicated that the atypical expression of circulating lncRNAs in various biological bodily fluids has a noteworthy impact on the early detection, pathological categorization, staging, monitoring of therapy outcomes, and evaluation of prognosis in cases of BC. This article aims to assess the potential clinical utility of circulating lncRNAs in the context of BC focusing on specific primary signaling pathways; Wnt/β-catenin, Notch, TGF-β, and hedgehog (Hh), in addition to some therapeutic interventions.
乳腺癌（BC）在全球范围内位居女性之首。肿瘤具有显著的异质性，表现出明显的药物耐药性、复发和转移，是最致命的恶性肿瘤之一。及时识别、持续评估治疗干预措施以及准确预测结果对于确定 BC 女性的总体生存率至关重要。然而，缺乏精确的生物标志物仍然是影响 BC 患者整体健康状况以及身心健康的重要决定因素。长链非编码 RNA（lncRNA）对多个基因和信号通路进行调控，因此在肿瘤生长的发展中起着关键作用。最近的研究表明，各种生物体液中循环 lncRNA 的异常表达对 BC 的早期检测、病理分类、分期、治疗效果监测和预后评估具有重要意义。本文旨在评估循环 lncRNA 在 BC 中的潜在临床应用价值，重点关注特定的主要信号通路；Wnt/β-catenin、Notch、TGF-β 和 hedgehog（Hh），以及一些治疗干预措施。
