Wang Jinxu, Miao Xiaolei, Sun Yi, Li Sijie, Wu Anshi, Wei Changwei
Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Brain Sci. 2023 Mar 24;13(4):538. doi: 10.3390/brainsci13040538.
Dopamine is an important neurotransmitter that plays a biological role by binding to dopamine receptors. The dopaminergic system regulates neural activities, such as reward and punishment, memory, motor control, emotion, and sleep-wake. Numerous studies have confirmed that the dopaminergic system has the function of maintaining wakefulness in the body. In recent years, there has been increasing evidence that the sleep-wake cycle in the brain has similar neurobrain network mechanisms to those associated with the loss and recovery of consciousness induced by general anesthesia. With the continuous development and innovation of neurobiological techniques, the dopaminergic system has now been proved to be involved in the emergence from general anesthesia through the modulation of neuronal activity. This article is an overview of the dopaminergic system and the research progress into its role in wakefulness and general anesthesia recovery. It provides a theoretical basis for interpreting the mechanisms regulating consciousness during general anesthesia.
多巴胺是一种重要的神经递质，通过与多巴胺受体结合发挥生物学作用。多巴胺能系统调节神经活动，如奖赏与惩罚、记忆、运动控制、情绪和睡眠-觉醒。大量研究证实，多巴胺能系统具有维持机体清醒的功能。近年来，越来越多的证据表明，大脑中的睡眠-觉醒周期具有与全身麻醉诱导的意识丧失和恢复相关的类似神经脑网络机制。随着神经生物学技术的不断发展与创新，现已证明多巴胺能系统通过调节神经元活动参与全身麻醉后的苏醒。本文综述了多巴胺能系统及其在觉醒和全身麻醉恢复中作用的研究进展。它为解释全身麻醉期间意识调节机制提供了理论基础。
