Department of Chemistry, University of Delhi, Delhi-110007, India.
Department of Physics and Astrophysics, University of Delhi, Delhi-110007, India.
J Mater Chem B. 2023 May 31;11(21):4785-4798. doi: 10.1039/d2tb02447k.
Magnetic nanoparticles (MNPs) have captivated the scientific community towards biomedical applications owing to their numerous distinctive physio-chemical properties. In this work, cobalt ferrite (CFNPs) and iron oxide nanoparticles (IONPs) were synthesized using the thermal decomposition method and then functionalized with polyacrylic acid (PAA) for aqueous dispersion. Associated techniques, namely TEM, FESEM, DLS, XRD, and VSM, were used to characterize the synthesized nanoparticles. We also investigated the light-induced and magnetic-field-induced hyperthermia properties of the PAA-functionalized MNPs. It was found that the PAA-CFNPs show a high specific absorption rate (SAR) compared with the PAA-IONPs. Since blood plasma is essential for the delivery and targeting of drugs, studying biological interactions is crucial for effective therapeutic use. Therefore, we performed physical and studies to probe into the mechanistic interaction of CFNPs and IONPs with human hemoglobin. From these studies, we inferred the successful binding between the nanoparticles and protein. Preliminary cytocompatibility and photothermal toxicity studies in breast cancer (MCF-7) cells treated with the nanoparticles revealed a low dark toxicity and significant laser-induced photothermal toxicity.
磁性纳米粒子（MNPs）由于其众多独特的物理化学性质，引起了科学界对生物医学应用的关注。在这项工作中，使用热分解法合成了钴铁氧体（CFNPs）和氧化铁纳米粒子（IONPs），然后用聚丙烯酸（PAA）进行功能化以实现水分散。使用 TEM、FESEM、DLS、XRD 和 VSM 等相关技术对合成的纳米粒子进行了表征。我们还研究了 PAA 功能化 MNPs 的光诱导和磁场诱导的热疗性能。结果发现，与 PAA-IONPs 相比，PAA-CFNPs 具有更高的比吸收率（SAR）。由于血浆对于药物的输送和靶向至关重要，因此研究生物相互作用对于有效治疗至关重要。因此，我们进行了物理和生化研究，以探究 CFNPs 和 IONPs 与人血红蛋白的相互作用机制。从这些研究中，我们推断出纳米粒子与蛋白质之间的成功结合。初步的细胞相容性和光热毒性研究表明，用纳米粒子处理的乳腺癌（MCF-7）细胞的暗毒性低，激光诱导的光热毒性显著。
