Brailowsky S, Knight R T, Efron R
Brain Res. 1986 Jun 18;376(1):71-7. doi: 10.1016/0006-8993(86)90900-5.
The effects of systemic phenytoin administration on the motor deficit resulting from a cortical lesion were studied in rats trained to walk coordinately on a narrow beam. The somatomotor cortex lesion was produced by an indwelling cannula through which saline or GABA were infused chronically via an osmotic minipump. Phenytoin (50 mg/kg i.p.) administered between days 3 and 5 after the intracortical catheter implantation produced a significant increase in the severity of the resulting hemiplegic syndrome. This DPH effect was more noticeable in those animals also receiving intracortical GABA infusions. The anticonvulsant at the dose used had no effect on motor performance when administered preoperatively or when given to the animals 14 days after surgical intervention when their hemiplegic syndrome had cleared. These findings suggest that phenytoin administration to brain-damaged individuals in the initial postlesion stage may be deleterious.
在训练有素的大鼠在窄梁上协调行走的实验中，研究了全身给予苯妥英对皮质损伤所致运动功能缺损的影响。通过留置套管造成躯体运动皮质损伤，通过渗透微型泵经该套管长期注入生理盐水或γ-氨基丁酸（GABA）。在皮质内导管植入后第3天至第5天给予苯妥英（50mg/kg腹腔注射），导致所产生的偏瘫综合征严重程度显著增加。这种苯妥英钠的作用在那些也接受皮质内GABA输注的动物中更为明显。术前给予该剂量的抗惊厥药对运动表现没有影响，在手术干预14天后当动物的偏瘫综合征已消除时给予也无影响。这些发现表明，在损伤后的初始阶段给脑损伤个体使用苯妥英可能是有害的。
