Goldstein L B
Department of Medicine (Neurology), Duke University, Durham, NC 27719, USA.
J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):753-5. doi: 10.1136/jnnp.58.6.753.
Fundamental studies in laboratory animals show that certain drugs influence behavioural recovery after brain injury. Although some drugs have the potential to enhance recovery, others may be detrimental. The purpose of the present study was to determine how often these potentially detrimental drugs are used in the management of patients with traumatic brain injury. The medical records of 100 patients with head trauma admitted to a university hospital during one year were reviewed and the frequencies of medication prescriptions during the stay in hospital were recorded. Only 14% of patients with head injury were taking medications at the time of injury. All of the patients were prescribed medications during their stay in hospital. Seventy two per cent of the patients received one or a combination of the drugs (neuroleptics and other central dopamine receptor antagonists, benzodiazepines, and the anticonvulsants phenytoin and phenobarbitone) that animal studies suggest may impair recovery. Until the true impact of these classes of drugs on the recovery process is better understood, care should be exercised in their use.
对实验动物的基础研究表明，某些药物会影响脑损伤后的行为恢复。虽然有些药物有可能促进恢复，但其他药物可能有害。本研究的目的是确定这些潜在有害药物在创伤性脑损伤患者治疗中使用的频率。回顾了一所大学医院在一年内收治的100例头部外伤患者的病历，并记录了住院期间药物处方的频率。只有14%的头部受伤患者在受伤时正在服用药物。所有患者在住院期间都开了药。72%的患者接受了动物研究表明可能会损害恢复的一种或几种药物（抗精神病药和其他中枢多巴胺受体拮抗剂、苯二氮卓类药物以及抗惊厥药苯妥英和苯巴比妥）。在更好地了解这些药物类别对恢复过程的真正影响之前，应谨慎使用它们。
