Center for Observational and Real-World Evidence, MSD Spain, Madrid, Spain.
Adelphi Values Ltd, Bollington, UK.
Adv Ther. 2023 Jul;40(7):3056-3069. doi: 10.1007/s12325-023-02509-x. Epub 2023 May 17.
Lung cancer accounts for approximately 20% of all cancer-related deaths and for the loss of 3.2 million disability-adjusted life years (DALYs) annually across Europe. The present study investigated the productivity losses resulting from premature deaths due to lung cancer in four European countries.
The human capital approach (HCA) was used to estimate indirect cost of productivity losses due to premature death due to lung cancer (ICD-10 codes C33-34 malignant neoplasm of trachea, bronchus, and lung) in Belgium, the Netherlands, Norway, and Poland. Years of productive life lost (YPLL) and present value of future lost productivity (PVFLP) were calculated using national age-specific mortality, wages, and employment rates. Data were sourced from the World Health Organization, Eurostat, and the World Bank.
In 2019, there were 41,468 lung cancer deaths in the included countries resulting in 59,246 YPLL and more than €981 million in productivity losses due to premature mortality. From 2010 to 2015, the PVFLP of lung cancer decreased by 14% in Belgium, 13% in the Netherlands, 33% in Norway, and 19% in Poland. From 2015 to 2019, the PVFLP of lung cancer decreased by 26% in Belgium, 27% in the Netherlands, 14% in Norway, and 38% in Poland.
The results from this study illustrate a decreasing trend in productivity costs of premature mortality due to lung cancer, as illustrated by the decreasing PVFLP between 2010 and 2019. This trend could be driven by a shift in the distribution of deaths towards older age groups due to advancements in the preventative and treatment landscape. These results provide an economic measure of the lung cancer burden which may assist decision-makers in allocating scarce resources amongst competing priorities in the included countries.
肺癌约占所有癌症相关死亡人数的 20%，每年在欧洲造成 320 万人残疾调整生命年（DALY）损失。本研究调查了四个欧洲国家因肺癌过早死亡导致的生产力损失。
使用人力资本法（HCA）估算因肺癌（ICD-10 编码 C33-34 气管、支气管和肺癌恶性肿瘤）过早死亡导致的间接生产力损失成本（IC）。在比利时、荷兰、挪威和波兰，使用国家特定年龄的死亡率、工资和就业率计算生产性生命损失年数（YPLL）和未来生产力损失的现值（PVFLP）。数据来自世界卫生组织、欧盟统计局和世界银行。
2019 年，纳入研究的国家中有 41468 例肺癌死亡，导致 59246 年 YPLL 和超过 9.81 亿欧元的过早死亡导致的生产力损失。从 2010 年到 2015 年，比利时肺癌的 PVFLP 下降了 14%，荷兰下降了 13%，挪威下降了 33%，波兰下降了 19%。从 2015 年到 2019 年，比利时肺癌的 PVFLP 下降了 26%，荷兰下降了 27%，挪威下降了 14%，波兰下降了 38%。
本研究结果表明，由于预防和治疗领域的进步，导致年龄较大的人群死亡分布发生变化，肺癌过早死亡导致的生产力成本呈下降趋势。这些结果提供了一个衡量肺癌负担的经济指标，可能有助于决策者在纳入研究的国家内分配有限资源以应对竞争优先事项。
