Department of Internal Medicine, School of Medicine, Cancer Prevention Research Center, Seyyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Pathol Res Pract. 2023 Jun;246:154507. doi: 10.1016/j.prp.2023.154507. Epub 2023 May 6.
LncRNAs, or long non-coding RNAs, are a subset of RNAs that play a regulatory role in a wide range of biological functions, including RNA processing, epigenetic regulation, and signal transduction. Recent research indicates that lncRNAs play a key role in the development and spread of cancer by being dysregulated in the disease. In addition, lncRNAs have been linked to the overexpression of certain proteins that are involved in tumor development and progression. Resveratrol has anti-inflammatory and anti-cancer properties that it exerts through regulating different lncRNAs. By the regulation of tumor-supportive and tumor-suppressive lncRNAs, resveratrol acts as an anti-cancer agent. By downregulating the tumor-supportive lncRNAs DANCR, MALAT1, CCAT1, CRNDE, HOTAIR, PCAT1, PVT1, SNHG16, AK001796, DIO3OS, GAS5 and H19, and upregulating MEG3, PTTG3P, BISPR, PCAT29, GAS5, LOC146880, HOTAIR, PCA3, NBR2, this herbal remedy causes apoptosis and cytotoxicity. For the purpose of using polyphenols in cancer therapy, it would be helpful to have more in-depth knowledge about lncRNA modulation via resveratrol. Here, we discuss the current knowledge and future promise of resveratrol as modulators of lncRNAs in different cancers.
LncRNAs，即长非编码 RNA，是一类在广泛的生物学功能中发挥调节作用的 RNA 分子，包括 RNA 加工、表观遗传调控和信号转导。最近的研究表明，lncRNAs 在疾病中失调，在癌症的发生和扩散中起着关键作用。此外，lncRNAs 与某些在肿瘤发生和进展中起作用的蛋白质的过表达有关。白藜芦醇具有抗炎和抗癌特性，它通过调节不同的 lncRNAs 发挥作用。通过调节肿瘤支持性和肿瘤抑制性 lncRNAs，白藜芦醇作为一种抗癌剂发挥作用。通过下调肿瘤支持性 lncRNAs DANCR、MALAT1、CCAT1、CRNDE、HOTAIR、PCAT1、PVT1、SNHG16、AK001796、DIO3OS、GAS5 和 H19，并上调 MEG3、PTTG3P、BISPR、PCAT29、GAS5、LOC146880、HOTAIR、PCA3、NBR2，这种草药疗法会导致细胞凋亡和细胞毒性。为了将多酚类物质应用于癌症治疗，深入了解白藜芦醇通过 lncRNA 的调节作用将是有帮助的。在这里，我们讨论了白藜芦醇作为不同癌症中 lncRNA 调节剂的现有知识和未来前景。
