Gholamalizadeh Maryam, Jonoush Mona, Mobarakeh Khadijeh Abbasi, Amjadi Arezoo, Alami Farkhondeh, Valisoltani Neda, Askarpour Seyed Ali, Azizi-Tabesh Ghasem, Mohammadian Mohammad Keshavarz, Akbari Mohammad Esmail, Rajabibazl Masoumeh, Alemrajabi Mahdi, Poodineh Jafar, Sadeghi Hossein, Hosseinzadeh Payam, Dahka Samaneh Mirzaei, Badeli Mostafa, Jarrahi Seyed Alireza Mosavi, Doaei Saeid
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Nutr. 2023 Jul 20;10:1215559. doi: 10.3389/fnut.2023.1215559. eCollection 2023.
FTO gene is associated with obesity, dietary intake, and the risk of colorectal cancer (CRC). In this study, patients with colorectal cancer were assessed for the interactions between FTO gene polymorphisms and dietary intake.
This case-control study was carried out on 450 participants aged 35-70 years including 150 patients with colorectal cancer and 300 healthy controls. Blood samples were collected in order to extract DNA and genotyping of FTO gene for rs9939609 polymorphism. A validated 168-item food frequency questionnaire (FFQ) and the Nutritionist-IV software were used to assess dietary intake.
In the participants with the TT genotype of FTO rs9939609 polymorphism, CRC risk was significantly associated with higher intake of dietary fat (OR:1.87 CI95%:1.76-1.99, = 0.04), vitamin B3 (OR:1.20 CI95%:1.08-1.65, = 0.04), and vitamin C (OR:1.06 CI95%:1.03-1.15, = 0.04) and lower intake of β-carotene (OR:0.98 CI95%:0.97-0.99, = 0.03), vitamin E (OR:0.77 CI95%:0.62-0.95, = 0.02), vitamin B1 (OR:0.15 CI95%:0.04-0.50, < 0.01), and biotin (OR:0.72 CI95%:0.0.57-0.92, = 0.01). No significant association was found between CRC and dietary intake in carriers of AA/AT genotypes after adjustments for the confounders.
CRC risk may be decreased by β-carotene, vitamins E, B1, and biotin only in those without the risk allele of the FTO gene. The association of CRC and diet may be influenced by FTO genotype. Further studies are warranted.
FTO基因与肥胖、饮食摄入以及结直肠癌（CRC）风险相关。在本研究中，对结直肠癌患者的FTO基因多态性与饮食摄入之间的相互作用进行了评估。
本病例对照研究纳入了450名年龄在35至70岁之间的参与者，其中包括150名结直肠癌患者和300名健康对照。采集血样以提取DNA并对FTO基因rs9939609多态性进行基因分型。使用经过验证的168项食物频率问卷（FFQ）和Nutritionist-IV软件评估饮食摄入情况。
在FTO rs9939609多态性TT基因型的参与者中，结直肠癌风险与膳食脂肪摄入量较高（比值比：1.87，95%置信区间：1.76 - 1.99，P = 0.04）、维生素B3（比值比：1.20，95%置信区间：1.08 - 1.65，P = 0.04）和维生素C（比值比：1.06，95%置信区间：1.03 - 1.15，P = 0.04）显著相关，而与β-胡萝卜素摄入量较低（比值比：0.98，95%置信区间：0.97 - 0.99，P = 0.03）、维生素E（比值比：0.77，95%置信区间：0.62 - 0.95，P = 0.02）、维生素B1（比值比：0.15，95%置信区间：0.04 - 0.50，P < 0.01）和生物素（比值比：0.72，95%置信区间：0.57 - 0.92，P = 0.01）相关。在对混杂因素进行调整后，AA/AT基因型携带者的结直肠癌与饮食摄入之间未发现显著关联。
仅在那些没有FTO基因风险等位基因的人群中，β-胡萝卜素、维生素E、B1和生物素可能会降低结直肠癌风险。结直肠癌与饮食的关联可能受FTO基因型影响。有必要进行进一步研究。
