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骨科创伤损伤无菌翻修固定术后手术部位感染的发生率及相关因素。

Rate and factors associated with surgical site infection following aseptic revision fixation of orthopaedic trauma injuries.

机构信息

Royal Infirmary of Edinburgh, Little France, Edinburgh, EH16 4SA, UK.

University of Edinburgh, Edinburgh, UK.

出版信息

Eur J Orthop Surg Traumatol. 2023 Dec;33(8):3511-3517. doi: 10.1007/s00590-023-03573-3. Epub 2023 May 18.

Abstract

PURPOSE

The primary aim of this study was to define the rate of infection following revision of fixation for aseptic failure. The secondary aims were to identify factors associated with an infection following revision and patient morbidity following deep infection.

METHODS

A retrospective study was undertaken to identify patients who underwent aseptic revision surgery during a 3-year period (2017-2019). Regression analysis was used to identify independent factors associated with SSI.

RESULTS

Eighty-six patients were identified that met the inclusion criteria, with a mean age of 53 (range 14-95) years and 48 (55.8%) were female. There were 15 (17%) patients with an SSI post revision surgery (n = 15/86). Ten percent (n = 9) of all revisions acquired a 'deep infection', which carried a high morbidity with a total of 23 operations, including initial revision, being undertaken for these patients as salvage procedures and three progressed to an amputation. Alcohol excess (odds ratio (OR) 1.61, 95% CI 1.01-6.36, p = 0.046) and chronic obstructive pulmonary disease (OR 11.1, 95% CI 1.00-133.3, p = 0.050) were independently associated with an increased risk of SSI.

CONCLUSION

Aseptic revision surgery had a high rate of SSI (17%) and deep infection (10%). All deep infections occurred in the lower limb with the majority of these seen in ankle fractures. Alcohol excess and COPD were independent risk factors associated with an SSI and patients with a history of these should be counselled accordingly.

LEVEL OF EVIDENCE

Retrospective Case Series, Level IV.

摘要

目的

本研究的主要目的是确定无菌失败后翻修固定的感染率。次要目的是确定翻修后感染的相关因素以及深部感染后的患者发病率。

方法

对 3 年内(2017-2019 年)进行无菌翻修手术的患者进行回顾性研究。采用回归分析确定与 SSI 相关的独立因素。

结果

确定了 86 名符合纳入标准的患者,平均年龄为 53 岁(范围 14-95 岁),48 名(55.8%)为女性。有 15 名(17%)患者在翻修后发生 SSI(n=15/86)。10%(n=9)的所有翻修术均发生“深部感染”,这些患者的发病率很高,总共进行了 23 次手术,包括对这些患者进行初次翻修作为挽救性手术,有 3 例进展为截肢。酒精过量(比值比(OR)1.61,95%可信区间 1.01-6.36,p=0.046)和慢性阻塞性肺疾病(OR 11.1,95%可信区间 1.00-133.3,p=0.050)与 SSI 风险增加独立相关。

结论

无菌翻修术的 SSI(17%)和深部感染(10%)发生率较高。所有深部感染均发生在下肢,其中大多数见于踝关节骨折。酒精过量和 COPD 是与 SSI 相关的独立危险因素,对此类患者应进行相应的咨询。

证据水平

回顾性病例系列,IV 级。

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J Am Acad Orthop Surg Glob Res Rev. 2022 Sep 23;6(9). doi: 10.5435/JAAOSGlobal-D-22-00196. eCollection 2022 Sep 1.
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The epidemiology of reoperations for orthopaedic trauma.骨科创伤再次手术的流行病学
Ann R Coll Surg Engl. 2015 Jan;97(1):40-5. doi: 10.1308/003588414X14055925059318.

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