Duong Lisa K, Corbali Halil Ibrahim, Riad Thomas S, Ganjoo Shonik, Nanez Selene, Voss Tiffany, Barsomium Hampartsum, Welsh James, Cortez Maria Angelica
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Department of Medical Pharmacology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Front Oncol. 2023 May 2;13:1187279. doi: 10.3389/fonc.2023.1187279. eCollection 2023.
Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.
脂质是一类多样的生物分子，它们与癌症病理生理学以及一系列免疫反应有关，使其成为改善免疫反应性的潜在靶点。脂质和脂质氧化也会影响肿瘤进展及对治疗的反应。尽管脂质在细胞功能中的重要性及其作为癌症生物标志物的潜力已得到探索，但脂质作为一种可能的癌症治疗形式尚未得到广泛研究。本综述探讨了脂质在癌症病理生理学中的作用，并描述了对这些大分子的进一步了解如何能够催生癌症的新型治疗方法。
