Avdieiev Oleksii, Denisov Sergey A, Ajeer Ashkan, Adams Lois, Greenwood Charlene, Nesbitt Heather, Thomas Keith, Rogers Keith, Solovyeva Olga, Mourokh Lev, Lazarev Pavel
EosDx UK Ltd., 5 New Street Square, London EC4A 3TW, UK.
Institut de Chimie Physique, UMR8000, CNRS, Université Paris-Saclay, Bât. 349, 91405 Orsay, France.
Life (Basel). 2025 Jun 3;15(6):904. doi: 10.3390/life15060904.
Structural biomarkers determined by X-ray scattering of the tissues can complement conventional diagnostics and provide a pathway for early detection of diseases. In the present study, mouse models were utilized to observe the progression of prostate cancer. We induced cancer in the left lobe of the mouse prostate, whilst the right lobe was left uninoculated. The mice were sacrificed at increasing systematic time points, and lobe samples were subsequently analyzed using X-ray scattering. Control samples were also collected from healthy mice sacrificed at the same time points. This investigation revealed that the ratio between the X-ray scattering peaks associated with the lipids and water can serve as a structural biomarker of cancer, and this biomarker develops as the tumor advances. The obtained cancer trajectory can serve as a baseline for the determination of the disease stage, and the biomarker movement along the trajectory can be evidence of the healing or disease progression.
通过组织的X射线散射确定的结构生物标志物可以补充传统诊断方法，并为疾病的早期检测提供途径。在本研究中，利用小鼠模型观察前列腺癌的进展。我们在小鼠前列腺的左叶诱导癌症，而右叶未接种。在增加的系统时间点处死小鼠，随后使用X射线散射分析叶样本。同时也从在相同时间点处死的健康小鼠中收集对照样本。这项研究表明，与脂质和水相关的X射线散射峰之间的比率可以作为癌症的结构生物标志物，并且随着肿瘤的进展，这种生物标志物会发生变化。所获得的癌症轨迹可以作为确定疾病阶段的基线，并且生物标志物沿着轨迹的变化可以作为愈合或疾病进展的证据。
