利用化学交换：Tm(iii) 配合物的 F 磁共振 OFF/ON 锌传感。
Harnessing chemical exchange: F magnetic resonance OFF/ON zinc sensing with a Tm(iii) complex.
机构信息
Department of Chemistry, The University of Texas at Austin, 105 E. 24th St Stop A5300, Austin, Texas 78712, USA.
出版信息
Chem Commun (Camb). 2020 Jun 11;56(46):6257-6260. doi: 10.1039/d0cc01876g. Epub 2020 May 6.
A fluorinated, thulium(iii) complex (Tm-PFZ-1) serves as an off-on F magnetic resonance probe for Zn(ii). Rapid exchange among different conformations combined with paramagnetic relaxation and chemical shift effects of Tm(iii) effectively eliminate the F NMR/MRI signal in Tm-PFZ-1. Chelation of Zn(ii) induces increased structural rigidity and reduces exchange rate, affording a robust F NMR/MRI signal. Tm-PFZ-1 represents a first-in-class paramagnetic F MR agent that exploits a novel sensing mechanism for Zn(ii) and is the first F MR-based scaffold to provide an "off-on" response to Zn(ii) in aqueous solution.
一种氟化的铥（III）配合物（Tm-PFZ-1）可用作用于 Zn（II）的开-关 F 磁共振探针。不同构象之间的快速交换以及铥（III）的顺磁弛豫和化学位移效应有效地消除了 Tm-PFZ-1 中的 F NMR/MRI 信号。Zn（II）的螯合作用会增加结构刚性并降低交换速率，从而提供强的 F NMR/MRI 信号。Tm-PFZ-1 代表了一类新型的顺磁 F 磁共振造影剂，它利用了一种新颖的 Zn（II）传感机制，并且是第一个基于 F 磁共振的支架，在水溶液中对 Zn（II）产生“开-关”响应。
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