Agoston D V, Kuhnt U
Exp Brain Res. 1986;62(3):663-8. doi: 10.1007/BF00236048.
A combined electrophysiological and neurochemical study was performed on the CA1 area of hippocampal slices in an attempt to identify changes in presynaptic nerve terminal function in long-term potentiation (LTP). After controlled induction of LTP in CA1, the activated region was subjected to subcellular fractionation followed by 45Ca2+ uptake determinations. Synaptosomes prepared from slices in which LTP has been induced showed a faster risetime and a higher level of saturation for K+-induced Ca-uptake than those derived from unstimulated and stimulated control slices. These findings point to a participation of presynaptic terminals in long-term potentiation.
为了确定长时程增强（LTP）过程中突触前神经末梢功能的变化，对海马切片的CA1区进行了电生理和神经化学联合研究。在CA1区控制性诱导LTP后，对激活区域进行亚细胞分级分离，然后测定45Ca2+摄取量。与未刺激和刺激对照切片制备的突触体相比，从诱导了LTP的切片制备的突触体显示出更快的上升时间和更高水平的K+诱导的Ca摄取饱和度。这些发现表明突触前末梢参与了长时程增强。
