Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.
Trends Neurosci. 2023 Jul;46(7):551-565. doi: 10.1016/j.tins.2023.04.007. Epub 2023 May 18.
The vasculature is increasingly recognized to impact brain function in health and disease across the life span. During embryonic brain development, angiogenesis and neurogenesis are tightly coupled, coordinating the proliferation, differentiation, and migration of neural and glial progenitors. In the adult brain, neurovascular interactions continue to play essential roles in maintaining brain function and homeostasis. This review focuses on recent advances that leverage single-cell transcriptomics of vascular cells to uncover their subtypes, their organization and zonation in the embryonic and adult brain, and how dysfunction in neurovascular and gliovascular interactions contributes to the pathogenesis of neurodegenerative diseases. Finally, we highlight key challenges for future research in neurovascular biology.
脉管系统越来越被认为会影响整个生命周期中大脑在健康和疾病状态下的功能。在胚胎大脑发育过程中，血管生成和神经发生紧密耦联，协调神经和神经胶质前体细胞的增殖、分化和迁移。在成人的大脑中，神经血管相互作用继续在维持大脑功能和内稳态方面发挥着重要作用。这篇综述侧重于利用血管细胞的单细胞转录组学来揭示其亚型的最新进展，以及它们在胚胎和成年大脑中的组织和分区方式，以及神经血管和神经胶质血管相互作用的功能障碍如何导致神经退行性疾病的发病机制。最后，我们强调了神经血管生物学未来研究的关键挑战。
