Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
J Nanobiotechnology. 2023 May 21;21(1):162. doi: 10.1186/s12951-023-01929-9.
Large-scale skin damage brings potential risk to patients, such as imbalance of skin homeostasis, inflammation, fluid loss and bacterial infection. Moreover, multidrug resistant bacteria (MDRB) infection is still a great challenge for skin damage repair. Herein, we developed an injectable self-healing bioactive nanoglass hydrogel (FABA) with robust antibacterial and anti-inflammatory ability for normal and Methicillin-resistant Staphylococcus aureus (MRSA) infected skin wound repair. FABA hydrogel was fabricated facilely by the self-crosslinking of F127-CHO (FA) and alendronate sodium (AL)-decorated Si-Ca-Cu nanoglass (BA). FABA hydrogel could significantly inhibit the growth of Staphylococcus aureus, Escherichia coli and MRSA in vitro, while showing good cytocompatibility and hemocompatibility. In addition, FABA hydrogel could inhibit the expression of proinflammatory factor TNF-α and enhance the expression of anti-inflammatory factor IL-4/ IL-10. Based on its versatility, FABA hydrogel could complete wound closure efficiently (75% at day 3 for normal wound, 70% at day 3 for MRSA wound), which was almost 3 times higher than control wound, which was related with the decrease of inflammatory factor in early wound. This work suggested that FABA hydrogel could be a promising dressing for acute and MRSA-infected wound repair.
大面积皮肤损伤会给患者带来潜在风险，如皮肤内稳态失衡、炎症、体液流失和细菌感染。此外，耐多药细菌（MDRB）感染仍然是皮肤损伤修复的一大挑战。在此，我们开发了一种具有强大抗菌和抗炎能力的可注射自修复生物活性纳米玻璃水凝胶（FABA），可用于正常和耐甲氧西林金黄色葡萄球菌（MRSA）感染的皮肤伤口修复。FABA 水凝胶通过 F127-CHO（FA）和载有阿仑膦酸钠（AL）的 Si-Ca-Cu 纳米玻璃（BA）的自交联制备。FABA 水凝胶可显著抑制金黄色葡萄球菌、大肠杆菌和 MRSA 的体外生长，同时表现出良好的细胞相容性和血液相容性。此外，FABA 水凝胶可抑制促炎因子 TNF-α的表达，增强抗炎因子 IL-4/IL-10 的表达。基于其多功能性，FABA 水凝胶可有效完成伤口闭合（正常伤口第 3 天闭合 75%，MRSA 伤口第 3 天闭合 70%），几乎是对照伤口的 3 倍，这与早期伤口中炎症因子的减少有关。这项工作表明，FABA 水凝胶可成为一种有前途的急性和 MRSA 感染伤口修复敷料。
