Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China.
Research Centre of Immunity, Trauma and Environment Medicine, Collaborative Innovation Centre of Medical Equipment, PLA Key Laboratory of Biological Damage Effect and Protection, Luoyang, China.
J Biomed Mater Res A. 2024 Mar;112(3):390-401. doi: 10.1002/jbm.a.37636. Epub 2023 Nov 9.
The repair of methicillin-resistant staphylococcus aureus (MRSA) infected wounds remains a serious challenge. Development of multifunctional bioactive hydrogels has shown promising potential in treating MRSA wound. Ferulic acid has special bioactivities including antioxidant antiinflammation antibacterial capacities but limited in lack of engineering strategy for efficient treatment of MRSA infected wound. Herein, we developed a multifunctional bioactive poly(ferulic acid) copolymer (FPFA) for treating MRSA infected wound. FPFA could be self-assembled into hydrogel under body temperature and demonstrated the injectable, sprayable, self-healing, anti-inflammatory, antioxidant, and angiogenic activity. FPFA hydrogel also showed the good cytocompatibility, efficiently enhanced the endothelial cell migration, scavenged intracellular reactive oxygen species (ROS), inhibited the expression of inflammatory factors and enhanced the in vitro angiogenesis. The MRSA-infected wound model showed that FPFA could significantly inhibit the MRSA infection and excess inflammation, reinforce the angiogenesis, accelerate wound healing and skin tissue regeneration.
耐甲氧西林金黄色葡萄球菌（MRSA）感染伤口的修复仍然是一个严峻的挑战。多功能生物活性水凝胶的开发在治疗 MRSA 伤口方面显示出了巨大的潜力。阿魏酸具有抗氧化、抗炎、抗菌等特殊的生物活性，但由于缺乏有效的工程策略，限制了其在治疗 MRSA 感染伤口方面的应用。本研究开发了一种多功能生物活性聚阿魏酸共聚物（FPFA），用于治疗 MRSA 感染伤口。FPFA 在体温下自组装成水凝胶，具有可注射、可喷雾、自修复、抗炎、抗氧化和促血管生成活性。FPFA 水凝胶还表现出良好的细胞相容性，能够有效促进内皮细胞迁移，清除细胞内活性氧（ROS），抑制炎症因子的表达，增强体外血管生成。MRSA 感染伤口模型表明，FPFA 能显著抑制 MRSA 感染和过度炎症反应，促进血管生成，加速伤口愈合和皮肤组织再生。
