Mhando Husna B, Sahini Mtabazi G, Makangara John J
Department of Chemistry, College of Natural and Mathematical Sciences, The University of Dodoma, P.O. Box 338, Dodoma, Tanzania.
Heliyon. 2023 May 4;9(5):e15892. doi: 10.1016/j.heliyon.2023.e15892. eCollection 2023 May.
The aim of this research was to investigate the chemical profiles of from 11 Tanzanian regions using preliminary tests as well as instrumental analyses with GC-MS and LC-MS. Generally, all the seized samples tested positive for the presence of (Δ-THC. The preliminary test with Duquenois method followed by chloroform addition revealed the presence of Δ-tetrahydrocannabinol (Δ-THC) in all the samples. GC-MS analyses of the samples revealed the presence of nine cannabinoids including Δ-THC, Δ-THC, cannabidivarol, cannabidiol, Δ-tetrahydrocannabivarin (Δ-THCV), cannabichromene, cannabinol, caryophyllene, and cannabicouramaronone, whereas LC-MS chemical profiling revealed the presence 24 chemical substances, including 4 cannabinoids, 15 different types of drugs and 5 amino acids. The Pwani region had the highest percentage composition of Δ-THC (13.45%), the main psychoactive ingredient of followed by Arusha (10.92%) and Singida (10.08%). The sample from Kilimanjaro had the lowest percentage of Δ-THC (6.72%). Apart from cannabinoids, the majority of other chemical substances were found in the Dar es Salaam region sample, which could be attributed to the fact that the city is the epicenter of business rather than the cultivation area, implying that the samples were obtained from different sources and blended as a single package.
本研究的目的是通过初步测试以及气相色谱-质谱联用（GC-MS）和液相色谱-质谱联用（LC-MS）的仪器分析，调查来自坦桑尼亚11个地区的[具体物质未明确]的化学特征。总体而言，所有查获的样本对（Δ-四氢大麻酚）的检测均呈阳性。采用杜凯努瓦方法并添加氯仿进行的初步测试表明，所有样本中均存在Δ-四氢大麻酚（Δ-THC）。对样本的GC-MS分析显示存在9种大麻素，包括Δ-THC、Δ-四氢大麻酚、大麻二酚、大麻二酚、Δ-四氢大麻酚酸（Δ-THCV）、大麻色烯、大麻酚、石竹烯和大麻考马罗酮，而LC-MS化学分析显示存在24种化学物质，包括4种大麻素、15种不同类型的药物和5种氨基酸。滨海地区的Δ-THC含量百分比最高（13.45%），Δ-THC是[具体物质未明确]的主要精神活性成分，其次是阿鲁沙（10.92%）和辛吉达（10.08%）。乞力马扎罗地区的样本中Δ-THC的百分比最低（6.72%）。除大麻素外，大多数其他化学物质在达累斯萨拉姆地区的样本中被发现，这可能是因为该城市是商业中心而非种植区，这意味着样本来自不同来源并作为一个单一包裹混合在一起。
