Ciclitira P J, Ellis H J, Richards D, Kemeny D M
Int Arch Allergy Appl Immunol. 1986;80(3):258-61. doi: 10.1159/000234062.
We have measured IgG1, 2, 3 and 4 subclass antibodies to gliadin and casein in normal controls, treated and untreated coeliac patients. The amount of antibody in each subclass was determined separately as a titre and as a concentration, by reference to a standard curve. Both methods of quantitation, carried out in separate assays, yielded comparable results (IgG antibody r = 0.86, IgG1 antibody r = 0.89). In all the coeliac patients, the majority of antibody was IgG1, and little IgG2, 3, 4 antibody was detected. Untreated coeliac patients had higher titres of IgG and IgG1 antibodies to gliadin and casein compared with normal controls. In the treated coeliac patients compared with the normal controls, there was no significant difference between the titres of IgG and IgG1 antibodies to gliadin but there were higher titres to casein.
我们检测了正常对照组、接受治疗和未接受治疗的乳糜泻患者针对麦醇溶蛋白和酪蛋白的IgG1、2、3和4亚类抗体。通过参考标准曲线，分别将每个亚类中的抗体量确定为滴度和浓度。在单独的检测中进行的这两种定量方法产生了可比的结果（IgG抗体r = 0.86，IgG1抗体r = 0.89）。在所有乳糜泻患者中，大多数抗体为IgG1，几乎检测不到IgG2、3、4抗体。与正常对照组相比，未接受治疗的乳糜泻患者针对麦醇溶蛋白和酪蛋白的IgG和IgG1抗体滴度更高。与正常对照组相比，接受治疗的乳糜泻患者针对麦醇溶蛋白的IgG和IgG1抗体滴度没有显著差异，但针对酪蛋白的滴度更高。
