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1
Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies.低麸质饮食治疗成人乳糜泻：对空肠形态和血清抗麸质抗体的影响。
Gut. 1988 Nov;29(11):1564-8. doi: 10.1136/gut.29.11.1564.
2
Detection of continuing gluten ingestion in treated coeliac patients.检测接受治疗的乳糜泻患者持续摄入麸质的情况。
Br Med J. 1975 Mar 1;1(5956):486-8. doi: 10.1136/bmj.1.5956.486.
3
Antigliadin antibodies and gluten-free diet in dermatitis herpetiformis.疱疹样皮炎中的抗麦醇溶蛋白抗体与无麸质饮食
Acta Derm Venereol. 1985;65(4):291-7.
4
Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease.抗转谷氨酰胺酶抗体作为成人乳糜泻患者遵循无麸质饮食预测指标的可靠性
Am J Gastroenterol. 2003 May;98(5):1079-87. doi: 10.1111/j.1572-0241.2003.07284.x.
5
Compliance of adolescents with coeliac disease with a gluten free diet.患有乳糜泻的青少年对无麸质饮食的依从性。
Gut. 1991 Aug;32(8):881-5. doi: 10.1136/gut.32.8.881.
6
[Individual sensitivity of jejunal mucosa to small doses of gluten in coeliac disease ].[乳糜泻患者空肠黏膜对小剂量麸质的个体敏感性]
Wiad Lek. 2002;55(9-10):554-60.
7
Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet.尽管成年乳糜泻患者坚持无麸质饮食，但肠黏膜完全恢复的情况非常少见。
Aliment Pharmacol Ther. 2009 Jun 15;29(12):1299-308. doi: 10.1111/j.1365-2036.2009.03992.x. Epub 2009 Mar 3.
8
Intestinal antibody pattern of celiac disease: occurrence in patients with normal jejunal biopsy histology.乳糜泻的肠道抗体模式：空肠活检组织学正常患者中的出现情况。
Gastroenterology. 1993 May;104(5):1263-72. doi: 10.1016/0016-5085(93)90333-8.
9
Immunological phenomena in the jejunum and serum after reintroduction of dietary gluten in children with treated coeliac disease.接受治疗的乳糜泻患儿重新摄入膳食麸质后空肠和血清中的免疫现象。
J Clin Pathol. 1976 Jul;29(7):592-7. doi: 10.1136/jcp.29.7.592.
10
[Long-term study of patients with coeliac disease in childhood and adolescence: latent and transient coeliac disease].儿童和青少年乳糜泻患者的长期研究：潜伏性和暂时性乳糜泻
Klin Padiatr. 2003 Mar-Apr;215(2):76-81. doi: 10.1055/s-2003-38504.

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Mucosal Healing in Celiac Disease: A Necessary or Unrealistic Goal?乳糜泻的黏膜愈合：一个必要的还是不切实际的目标？
GE Port J Gastroenterol. 2020 Aug;27(5):299-301. doi: 10.1159/000507965. Epub 2020 Jun 11.
2
Comparison between gluten-free regime and regime with gluten in symptoms of patients with irritable bowel syndrome (IBS).无麸质饮食方案与含麸质饮食方案对肠易激综合征（IBS）患者症状影响的比较。
J Family Med Prim Care. 2019 May;8(5):1691-1695. doi: 10.4103/jfmpc.jfmpc_464_18.
3
Younger age at diagnosis predisposes to mucosal recovery in celiac disease on a gluten-free diet: A meta-analysis.诊断时年龄较小使乳糜泻患者在采用无麸质饮食时更易出现黏膜恢复：一项荟萃分析。
PLoS One. 2017 Nov 2;12(11):e0187526. doi: 10.1371/journal.pone.0187526. eCollection 2017.
4
Assessing of Celiac Disease and Nonceliac Gluten Sensitivity.乳糜泻和非乳糜泻麸质敏感的评估
Gastroenterol Res Pract. 2015;2015:723954. doi: 10.1155/2015/723954. Epub 2015 Apr 29.
5
The gluten-free diet and its current application in coeliac disease and dermatitis herpetiformis.无麸质饮食及其在乳糜泻和疱疹样皮炎中的应用现状。
United European Gastroenterol J. 2015 Apr;3(2):121-35. doi: 10.1177/2050640614559263.
6
The clinical response to gluten challenge: a review of the literature.对 gluten challenge 的临床反应：文献综述。
Nutrients. 2013 Nov 19;5(11):4614-41. doi: 10.3390/nu5114614.
7
Consumption of gluten with gluten-degrading enzyme by celiac patients: a pilot-study.乳糜泻患者摄入含谷氨酰胺酶的 gluten：一项初步研究。
World J Gastroenterol. 2013 Sep 21;19(35):5837-47. doi: 10.3748/wjg.v19.i35.5837.
8
Reintroduction of gluten following flour transamidation in adult celiac patients: a randomized, controlled clinical study.成年乳糜泻患者面粉转酰胺化后重新引入麸质：一项随机对照临床研究。
Clin Dev Immunol. 2012;2012:329150. doi: 10.1155/2012/329150. Epub 2012 Jul 31.
9
Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease.乳糜泻患者接受低剂量和中剂量 gluten 激发后的小肠黏膜变化和抗体应答。
BMC Gastroenterol. 2011 Nov 24;11:129. doi: 10.1186/1471-230X-11-129.
10
Dose dependent effects of protracted ingestion of small amounts of gliadin in coeliac disease children: a clinical and jejunal morphometric study.腹腔疾病儿童长期摄入少量麦醇溶蛋白的剂量依赖性效应：一项临床和空肠形态计量学研究。
Gut. 1993 Nov;34(11):1515-9. doi: 10.1136/gut.34.11.1515.

本文引用的文献

1
Wheat gliadin fractions and other cereal antigens reactive with antibodies in the sera of coeliac patients.小麦醇溶蛋白组分及其他与乳糜泻患者血清中的抗体发生反应的谷物抗原。
Clin Exp Immunol. 1982 Dec;50(3):651-60.
2
IgA anti-gliadin antibodies in coeliac disease.乳糜泻中的IgA抗麦醇溶蛋白抗体。
Clin Exp Immunol. 1981 Nov;46(2):286-93.
3
Gliadin antibody levels in screening tests for coeliac disease.乳糜泻筛查试验中的麦醇溶蛋白抗体水平。
Br Med J (Clin Res Ed). 1984 Jan 7;288(6410):69-71. doi: 10.1136/bmj.288.6410.69-b.
4
Alpha gliadin antibody levels: a serological test for coeliac disease.α-麦醇溶蛋白抗体水平：乳糜泻的血清学检测
Br Med J (Clin Res Ed). 1983 Jun 25;286(6383):2007-10. doi: 10.1136/bmj.286.6383.2007.
5
IgA antigliadin antibodies: a marker of mucosal damage in childhood coeliac disease.IgA抗麦醇溶蛋白抗体：儿童乳糜泻黏膜损伤的标志物。
Lancet. 1983 Feb 12;1(8320):320-2. doi: 10.1016/s0140-6736(83)91627-6.
6
Prognosis in early adult life of coeliac children treated with a gluten-free diet.采用无麸质饮食治疗的乳糜泻儿童在成年早期的预后。
Br Med J. 1969 May 17;2(5654):401-4. doi: 10.1136/bmj.2.5654.401.
7
Frequency and nature of relapses in children suffering from the malabsorption syndrome with gluten intolerance.患有麸质不耐受性吸收不良综合征儿童复发的频率和性质。
Acta Paediatr Scand. 1970 Sep;59(5):481-6. doi: 10.1111/j.1651-2227.1970.tb16795.x.
8
Quantitation of intraepithelial lymphocytes in human jejunum.人空肠上皮内淋巴细胞的定量分析
Gut. 1971 Dec;12(12):988-94. doi: 10.1136/gut.12.12.988.
9
110 children with coeliac disease, 1950-1969.1950年至1969年间的110名乳糜泻患儿。
Arch Dis Child. 1971 Aug;46(248):421-36. doi: 10.1136/adc.46.248.421.
10
Childhood celiac disease: response of treated patients to a small uniform daily dose of wheat gluten.儿童乳糜泻：接受治疗的患者对每日小剂量均匀麦麸的反应
J Pediatr. 1972 Nov;81(5):885-93. doi: 10.1016/s0022-3476(72)80538-9.

低麸质饮食治疗成人乳糜泻：对空肠形态和血清抗麸质抗体的影响。

Low gluten diet in the treatment of adult coeliac disease: effect on jejunal morphology and serum anti-gluten antibodies.

作者信息

Montgomery A M, Goka A K, Kumar P J, Farthing M J, Clark M L

机构信息

Department of Gastroenterology, St Bartholomew's Hospital, London.

出版信息

Gut. 1988 Nov;29(11):1564-8. doi: 10.1136/gut.29.11.1564.

DOI:10.1136/gut.29.11.1564
PMID:3209114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433820/
Abstract

Treatment of patients with coeliac disease with a low gluten containing diet (LGD) remains controversial. We have studied jejunal morphology and antigluten (AG) antibody titres by ELISA in patients on a LGD of 2.5-5 g/day for three to 14 months (median six months) and compared results with patients on a strict gluten free diet (GFD) for six to 27 months (median 13 months). We found no significant difference in villous height or crypt depth (eight LGD v 10 GFD patients) or serum AG-IgA, -IgG, and IgM titres (13 LGD v 12 GFD patients). there was however, a significant increase (p less than 0.05) in intra-epithelial lymphocytes in those patients on a LGD. We conclude that adult coeliac patients can tolerate a LGD without gross morphological change and without initiating significant AG antibody responses.

摘要

采用低麸质饮食（LGD）治疗乳糜泻患者仍存在争议。我们通过酶联免疫吸附测定法（ELISA）研究了每日摄入2.5 - 5克麸质的低麸质饮食患者空肠形态和抗麸质（AG）抗体滴度，这些患者接受低麸质饮食3至14个月（中位数为6个月），并将结果与接受严格无麸质饮食（GFD）6至27个月（中位数为13个月）的患者进行比较。我们发现绒毛高度或隐窝深度（8名低麸质饮食患者与10名无麸质饮食患者）或血清AG - IgA、- IgG和IgM滴度（13名低麸质饮食患者与12名无麸质饮食患者）无显著差异。然而，接受低麸质饮食的患者上皮内淋巴细胞有显著增加（p < 0.05）。我们得出结论，成年乳糜泻患者可以耐受低麸质饮食，而不会出现明显的形态学变化，也不会引发显著的AG抗体反应。