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巯基乙酸诱导的小鼠腹腔巨噬细胞产生肿瘤坏死因子对脂多糖持续存在的需求。

Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate-induced peritoneal murine macrophages.

作者信息

Gifford G E, Lohmann-Matthes M L

出版信息

Int J Cancer. 1986 Jul 15;38(1):135-7. doi: 10.1002/ijc.2910380121.

DOI:10.1002/ijc.2910380121
PMID:3721620
Abstract

This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production of TNF but the yield was limited to the amount that would have been produced had the LPS not been removed.

摘要

这项研究表明，巯基乙酸盐诱导的腹腔巨噬细胞产生肿瘤坏死因子（TNF）需要持续存在脂多糖（LPS）。在任何时间去除LPS都会导致TNF的进一步产生突然停止。重新添加LPS会导致TNF的进一步产生，但产量仅限于如果未去除LPS本应产生的量。

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Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation.
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