Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, No.155 Nanjing North Street, Heping District, Shenyang, 110001, China.
School of Medicine, Xiamen University, Xiamen, 361000, China.
Sci Rep. 2023 May 22;13(1):8265. doi: 10.1038/s41598-023-33861-1.
Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing biological effects during gastric carcinogenesis. Though diverse hypothetical mechanisms were reported, further tests were necessitated for authentication. Herein, this study pinpointed a representative circDYRK1A which screened from vast amounts of public data sets using surprisingly novel bioinformatics approaches together with validations from the in vitro findings and then concluded that circDYRK1A tethered the biological behavior and swayed the clinicopathological features with gastric cancer patients thus providing an in-depth awareness for gastric carcinoma.
几十年来，胃癌一直是公众健康的沉重负担之一，其发病率和死亡率都很高。作为 RNA 家族中的非常规模块，环状 RNA 在胃致癌过程中表现出显著的生物学效应。虽然报道了多种假设机制，但仍需要进一步的测试来验证。在本研究中，我们利用令人惊讶的新型生物信息学方法从大量公共数据集筛选出一个代表性的 circDYRK1A，并结合体外研究结果进行验证，结果表明 circDYRK1A 与胃癌患者的生物学行为有关，并影响其临床病理特征，从而为胃癌提供了更深入的认识。
