Environmental & Molecular Toxicology Department, College of Agricultural Sciences, Oregon State University, Corvallis, Oregon, USA.
Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, Oregon, USA.
Toxicol Sci. 2023 Jul 28;194(2):138-152. doi: 10.1093/toxsci/kfad051.
The existence of thousands of per- and polyfluoroalkyl substances (PFAS) and evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity and to move beyond one-chemical-at-a-time approaches to hazard assessment for this chemical class. The zebrafish model enables rapid assessment of large libraries of PFAS, powerful comparison of compounds in a single in vivo system, and evaluation across life stages and generations, and has led to significant advances in PFAS research in recent years. The focus of this review is to assess contemporary findings regarding PFAS toxicokinetics, toxicity and apical adverse health outcomes, and potential modes of action using the zebrafish model. Much of the peer-reviewed literature has focused on a small subset of PFAS structural subclasses, such as the perfluoroalkyl sulfonic acids and perfluoroalkyl carboxylic acids. However, recent data on more diverse PFAS structures are enabling prioritization of compounds of concern. Structure-activity comparisons and the utilization of modeling and 'omics technologies in zebrafish have greatly contributed to our understanding of the hazard potential for a growing number of PFAS and will surely inform our understanding and predictive capabilities for many more PFAS in the future.
存在数千种全氟和多氟烷基物质 (PFAS)，并且有证据表明其中一些会对健康产生不良影响，这就产生了巨大的需求，需要更好地了解 PFAS 的毒性，并超越对该类化学物质逐个进行危害评估的方法。斑马鱼模型能够快速评估大量 PFAS 化合物库，在单个体内系统中对化合物进行强大的比较，并在多个生命阶段和世代进行评估，近年来在 PFAS 研究方面取得了重大进展。本综述的重点是使用斑马鱼模型评估当代关于 PFAS 毒物动力学、毒性和顶端不良健康结果以及潜在作用模式的研究结果。同行评议文献的大部分重点关注 PFAS 结构子类的一小部分，例如全氟烷基磺酸和全氟烷基羧酸。然而，最近关于更多种类 PFAS 结构的数据正在优先考虑关注的化合物。结构-活性比较以及在斑马鱼中使用建模和“组学”技术极大地促进了我们对越来越多的 PFAS 危害潜力的理解，并必将为我们未来对更多的 PFAS 提供理解和预测能力。
