Department of Critical Care Medicine, Hunan Province Directly Affiliated TCM Hospital, Zhuzhou, China.
Department of Cardiovascular Medicine, Hunan Province Directly Affiliated TCM Hospital, Zhuzhou, China.
BMC Cardiovasc Disord. 2023 May 23;23(1):267. doi: 10.1186/s12872-023-03289-6.
Kounis syndrome is a rare clinical condition characterized by the occurrence of an acute coronary event induced by an acute allergic episode. The ongoing pandemic of coronavirus disease 2019 (COVID-19) has contributed to an increase in the incidence of allergic reactions to a certain extent, thereby increasing the incidence of Kounis syndrome. Timely diagnosis and effective management of this disease are important in clinical practice.
We report a 43-year-old woman who developed generalized pruritus, breathlessness, paroxysmal precordial crushing pain, and dyspnea after receiving the third dose of the COVID-19 vaccine. After anti-allergic treatment and therapy for acute myocardial ischemia, her symptoms resolved with improvement in cardiac function and resolution of ST-segment changes. The prognosis was satisfactory, and the final diagnosis was type I Kounis syndrome.
This patient with type I Kounis syndrome rapidly developed acute coronary syndrome (ACS) after an acute allergic reaction to the COVID-19 vaccine. Timely diagnosis of acute allergic reaction and ACS, and targeted treatment based on the relevant guidelines are the key to successful treatment of the syndrome..
Kounis 综合征是一种罕见的临床病症，其特征是急性过敏发作引发急性冠脉事件。目前 2019 冠状病毒病（COVID-19）大流行在一定程度上导致过敏反应的发生率增加，从而使 Kounis 综合征的发病率增加。及时诊断和有效管理该病在临床实践中非常重要。
我们报告了 1 例 43 岁女性，在接种 COVID-19 疫苗第 3 剂后出现全身瘙痒、呼吸困难、阵发性心前区压榨样疼痛和呼吸困难。经过抗过敏治疗和急性心肌缺血治疗后，其症状缓解，心功能改善，ST 段改变消失。预后良好，最终诊断为 I 型 Kounis 综合征。
本例 I 型 Kounis 综合征患者在 COVID-19 疫苗急性过敏反应后迅速发生急性冠脉综合征（ACS）。及时诊断急性过敏反应和 ACS，并根据相关指南进行有针对性的治疗是成功治疗该综合征的关键。
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