用于治疗下肢溃疡的细菌纤维素生物材料。

Bacterial cellulose biomaterials for the treatment of lower limb ulcers.

机构信息

- Universidade Federal de Pernambuco, Programa de Pós-graduação em Inovação Terapêutica - Laboratório de Biodispositivos Nanoestruturados, Departamento de Bioquímica - Recife - PE - Brasil.

- Universidade Federal de Pernambuco, Laboratório de Biodispositivos Nanoestruturados, Departamento de Bioquímica - Recife - PE - Brasil.

出版信息

Rev Col Bras Cir. 2023 May 22;50:e20233536. doi: 10.1590/0100-6991e-20233536-en. eCollection 2023.

Abstract

Chronic ulcers of the lower limbs are common and recurrent, especially in the elderly population, they are disabling injuries that generate a great socioeconomic burden. This scenario encourages the development of new, low-cost therapeutic alternatives. The present study aims to describe the use of bacterial cellulose in the treatment of lower limb ulcers. This is an integrative literature review, carried out in the PubMed and Science Direct databases by associating the descriptors, with the inclusion criteria being clinical studies in the last 5 years, available in full in English, Portuguese and Spanish. Five clinical trials were analyzed and the main therapeutic effects obtained in the experimental groups that used bacterial cellulose dressings were a reduction in the area of the wounds, one of the studies showed a reduction of 44.18cm2 in the area of the wound, the initial lesions measured on average 89.46cm2 and at the end of the follow-up, they had an average of 45.28cm2, since the reduction in pain and the decrease in the number of exchanges were advantages described in all groups that used the BS. It is concluded that BC dressings are an alternative for the treatment of lower limb ulcers, their use also reduces operational costs related to the treatment of ulcers.

摘要

下肢慢性溃疡较为常见且易复发,尤其在老年人群中,这些溃疡是导致残疾的损伤,给社会经济带来了巨大负担。这种情况促使人们开发新的、低成本的治疗方法。本研究旨在描述细菌纤维素在下肢溃疡治疗中的应用。这是一项综合文献回顾,在 PubMed 和 Science Direct 数据库中通过组合描述符进行,纳入标准为过去 5 年内的临床研究,且全文可提供英文、葡萄牙文和西班牙文版本。分析了 5 项临床试验,使用细菌纤维素敷料的实验组获得的主要治疗效果是减少了创面面积,其中一项研究显示创面面积减少了 44.18cm2,初始损伤平均为 89.46cm2,随访结束时平均为 45.28cm2,因为减轻疼痛和减少换药次数是所有使用 BS 的组中描述的优势。结论是,BC 敷料是治疗下肢溃疡的一种选择,其使用还降低了与溃疡治疗相关的运营成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9173/10508663/5635feb171d7/rcbc-50-e20233536-g001.jpg

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