Al Hawsawi Khalid, AlDoboke Amal W, Alsulami Seham A, Alamri Ghadeer E, Alsufi Raed F
Dermatology, King Abdulaziz Hospital, Makkah, SAU.
Medicine and Surgery, Umm Al-Qura University, Makkah, SAU.
Cureus. 2023 Apr 22;15(4):e37992. doi: 10.7759/cureus.37992. eCollection 2023 Apr.
There are few reports of dupilumab-induced psoriasis recently published. Here, we present a case of a 50-year-old female with a three-month history of persistent itchy scalp lesions. She had an unremarkable past medical history except that she was diagnosed with prurigo nodularis (PN) three years ago and was on dupilumab treatment for one year. Skin examination revealed multiple silvery scaly plaques on her scalp. The examination of the nails and mucous membranes was normal; there were no skin lesions. Based on the above clinical findings, the patient was diagnosed with dupilumab-induced scalp psoriasis. Dupilumab was stopped. Anti-psoriasis treatment (0.05% betamethasone dipropionate-calcepitriol gel) was started and the patient showed improvement. She was put under periodic follow-up.
最近很少有关于度普利尤单抗诱发银屑病的报道。在此，我们报告一例50岁女性病例，其头皮持续瘙痒性皮损已有3个月病史。她既往病史无特殊，只是3年前被诊断为结节性痒疹（PN），并接受了1年度普利尤单抗治疗。皮肤检查发现其头皮有多个银色鳞屑斑块。指甲和黏膜检查正常；无皮肤病变。基于上述临床发现，该患者被诊断为度普利尤单抗诱发的头皮银屑病。停用度普利尤单抗。开始抗银屑病治疗（0.05%丙酸倍他米松 - 骨化三醇凝胶），患者病情有所改善。她接受了定期随访。
