de la Fuente José, Artigas-Jerónimo Sara, Villar Margarita
SaBio, Instituto de Investigacion en Recursos Cinegeticos IREC-CSIC-UCLM-JCCM, 13005 Ciudad Real, Spain.
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Microlife. 2021 Nov 11;3:uqab012. doi: 10.1093/femsml/uqab012. eCollection 2022.
Ticks and tick-borne pathogens such as affect human and animal health worldwide and thus the characterization of host/tick-pathogen interactions is important for the control of tick-borne diseases. The vertebrate regulatory proteins Akirins and its tick ortholog, Subolesin, are conserved throughout the metazoan and involved in the regulation of different biological processes such as immune response to pathogen infection. Akirin/Subolesin have a key role in host/tick-pathogen interactions and exert its regulatory function primarily through interacting proteins such as transcription factors, chromatin remodelers and RNA-associated proteins. Recent results have provided evidence of / genetic interactions and the interaction of Akirin/Subolesin with histones, thus suggesting a role in direct chromatin remodeling. Finally, and still to be proven, some models suggest the possibility of direct Akirin/Subolesin protein interactions with DNA. Future research should advance the characterization of Akirin/Subolesin interactome and its functional role at the host/tick-pathogen interface. These results have implications for translational biotechnology and medicine for the development of new effective interventions for the control of ticks and tick-borne diseases.
蜱虫以及蜱虫传播的病原体，如……，在全球范围内影响着人类和动物的健康，因此宿主/蜱虫-病原体相互作用的特征对于控制蜱虫传播疾病至关重要。脊椎动物调节蛋白Akirins及其蜱虫直系同源物Subolesin在整个后生动物中保守，并参与不同生物过程的调节，如对病原体感染的免疫反应。Akirin/Subolesin在宿主/蜱虫-病原体相互作用中起关键作用，主要通过与转录因子、染色质重塑因子和RNA相关蛋白等相互作用蛋白发挥其调节功能。最近的研究结果提供了……/遗传相互作用以及Akirin/Subolesin与组蛋白相互作用的证据，从而表明其在直接染色质重塑中的作用。最后，一些模型提出Akirin/Subolesin蛋白与DNA直接相互作用的可能性，但仍有待证实。未来的研究应推进Akirin/Subolesin相互作用组的特征及其在宿主/蜱虫-病原体界面的功能作用的研究。这些结果对转化生物技术和医学开发控制蜱虫和蜱虫传播疾病的新有效干预措施具有启示意义。
