猴头菇菌丝体中的 Erinacine S 通过诱导神经甾体积累促进神经元再生。
Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation.
机构信息
Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan.
Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan.
出版信息
J Food Drug Anal. 2023 Mar 15;31(1):32-54. doi: 10.38212/2224-6614.3446.
Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.
从珊瑚菌属中提取的齿缘姬蛙素具有多种健康益处，包括对神经退行性疾病的神经保护作用，但具体机制尚不清楚。在这里，我们发现齿缘姬蛙素 S 以细胞自主的方式增强神经突生长。它促进 PNS 神经元损伤后的轴突再生，并增强 CNS 神经元抑制性底物上的再生。通过 RNA-seq 和生物信息学分析，发现齿缘姬蛙素 S 导致神经元中神经甾体的积累。通过 ELISA 和神经甾体生成抑制剂检测来验证这一效果。这项研究揭示了齿缘姬蛙素 S 对提高神经甾体水平的一个未知的作用。
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