Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Taiwan.
Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Taiwan.
J Food Drug Anal. 2023 Mar 15;31(1):32-54. doi: 10.38212/2224-6614.3446.
Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.
从珊瑚菌属中提取的齿缘姬蛙素具有多种健康益处，包括对神经退行性疾病的神经保护作用，但具体机制尚不清楚。在这里，我们发现齿缘姬蛙素 S 以细胞自主的方式增强神经突生长。它促进 PNS 神经元损伤后的轴突再生，并增强 CNS 神经元抑制性底物上的再生。通过 RNA-seq 和生物信息学分析，发现齿缘姬蛙素 S 导致神经元中神经甾体的积累。通过 ELISA 和神经甾体生成抑制剂检测来验证这一效果。这项研究揭示了齿缘姬蛙素 S 对提高神经甾体水平的一个未知的作用。
