Wu Hongkun, Qian Xingkai, Liang Guiyou
School of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Center for Translational Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Cardiovasc Drugs Ther. 2024 Dec;38(6):1111-1122. doi: 10.1007/s10557-023-07472-x. Epub 2023 May 25.
Small extracellular vesicles (SEVs) secreted by mesenchymal stromal cells (MSCs) are considered one of the most promising biological therapies in recent years. The protective effect of MSCs-derived SEVs on myocardium is mainly related to their ability to deliver cargo, anti-inflammatory properties, promotion of angiogenesis, immunoregulation, and other factors. Herein, this review focuses on the biological properties, isolation methods, and functions of SEVs. Then, the roles and potential mechanisms of SEVs and engineered SEVs in myocardial protection are summarized. Finally, the current situation of clinical research on SEVs, the difficulties encountered, and the future fore-ground of SEVs are discussed. In conclusion, although there are some technical difficulties and conceptual contradictions in the research of SEVs, the unique biological functions of SEVs provide a new direction for the development of regenerative medicine. Further exploration is warranted to establish a solid experimental and theoretical basis for future clinical application of SEVs.
间充质基质细胞（MSCs）分泌的小细胞外囊泡（SEVs）被认为是近年来最有前景的生物疗法之一。MSCs来源的SEVs对心肌的保护作用主要与其运载物质的能力、抗炎特性、促进血管生成、免疫调节及其他因素有关。本文综述聚焦于SEVs的生物学特性、分离方法及功能。然后，总结了SEVs及工程化SEVs在心肌保护中的作用及潜在机制。最后，讨论了SEVs临床研究的现状、遇到的困难及未来前景。总之，尽管SEVs研究存在一些技术难题和概念上的矛盾，但SEVs独特的生物学功能为再生医学发展提供了新方向。有必要进一步探索，为SEVs未来临床应用建立坚实的实验和理论基础。
