Laboratory of Genetics, Immunology, and Human Pathology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Anatomopathology Department, Mongi Slim Hospital, Tunis, Tunisia.
Mol Biol Rep. 2023 Jul;50(7):6177-6189. doi: 10.1007/s11033-023-08525-y. Epub 2023 May 25.
Over the past decades, obesity has grown to epidemic proportions worldwide. It has been associated with an increased risk for different types of cancer. In addition, obesity has been associated with a poor prognosis, an increased risk of metastasis and mortality, and resistance to anti-cancer therapies. The pathophysiological mechanisms underlying the obesity-cancer connection have not yet been fully elucidated. However, this connection could result, at least in part, from the action of adipokines, whose levels are increased in obesity. Among these adipokines, evidence suggests leptin's critical role in linking obesity to cancer. In this review, we first summarize the current state of the literature regarding the implication of leptin in tumorigenic processes. Next, we focus on the effects of leptin on the anti-tumor immune response. Then, we discuss the influence of leptin on the efficiency of antineoplastic treatments and the development of tumor resistance. Finally, we highlight the use of leptin as a potential target for the prevention and treatment of cancer.
在过去的几十年中，肥胖已在全球范围内蔓延成一种流行病。它与不同类型癌症的风险增加有关。此外，肥胖还与预后不良、转移和死亡率增加以及对癌症治疗的耐药性有关。肥胖与癌症之间的病理生理机制尚未完全阐明。然而，这种联系至少部分可能是由于脂肪因子的作用所致，脂肪因子在肥胖症中水平升高。在这些脂肪因子中，有证据表明瘦素在将肥胖与癌症联系起来方面起着关键作用。在这篇综述中，我们首先总结了目前关于瘦素在肿瘤发生过程中的作用的文献。接下来，我们重点介绍瘦素对抗肿瘤免疫反应的影响。然后，我们讨论了瘦素对抗肿瘤治疗效果和肿瘤耐药性发展的影响。最后，我们强调了将瘦素作为预防和治疗癌症的潜在靶点的重要性。
