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扩展携带者筛查在辅助生殖技术中的影响:改变了“游戏规则”——综述

The influence of expanded carrier screening in assisted reproductive techniques: changed the 'game'- review.

作者信息

Drettas Petros, Tatanis Vasileios, Spiliopoulou Chara, Adonakis Georgios, Liatsikos Evangelos

机构信息

Department of Urology, University of Patras, Patras, Greece.

Department of Forensic Medicine and Toxicology, School of Medicine, National and Kapodistrian University of Athens, Greece.

出版信息

Ann Med Surg (Lond). 2023 Apr 17;85(5):1811-1815. doi: 10.1097/MS9.0000000000000657. eCollection 2023 May.

Abstract

Expanded carrier screening constitutes a new scientific tool able to detect conditions that can be treated immediately after birth or during pregnancy. Its implementation could affect both the prenatal period and assisted reproductive techniques. It is strongly beneficial as it provides much useful information to future parents concerning the medical status of their offspring. In addition, the definition of 'serious/severe', regulating preimplantation diagnosis, donor insemination, and even the definitions of prerequisites for abortion diseases, should be reformed including all clinically severe diseases. On the other hand, controversies may arise especially regarding gamete donation. Future parents and offspring maybe informed regarding donors' demographic and medical characteristics. This study aims to investigate the effects of the implementation of expanded carrier screening in the reformation of the definition of 'severe/serious' disease, the decision-making of future parents, gamete donation, and the possible new moral dilemmas that may arise.

摘要

扩大携带者筛查是一种新的科学工具,能够检测出在出生后或怀孕期间即可立即治疗的病症。其实施可能会影响孕期以及辅助生殖技术。它具有极大的益处,因为它能为未来的父母提供许多有关其后代健康状况的有用信息。此外,对于“严重”的定义、植入前诊断、供体授精的规范,甚至堕胎疾病前提条件的定义,都应进行改革,纳入所有临床严重疾病。另一方面,可能会引发争议,尤其是在配子捐赠方面。未来的父母和后代可能会了解捐赠者的人口统计学和医学特征。本研究旨在探讨扩大携带者筛查的实施在“严重”疾病定义的改革、未来父母的决策、配子捐赠以及可能出现的新道德困境方面所产生的影响。

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